2. Gene
  3. KLRG1 - killer cell lectin like receptor G1 Gene

KLRG1 - killer cell lectin like receptor G1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：杀伤细胞凝集素样受体 G1

种属: Homo sapiens

同用名: 2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE

基因 ID: 10219 | 基因类型: protein coding

关于 KLRG1

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,950,044-9,215,570 (from NCBI)

This gene has 7 transcripts (splice variants), 107 orthologues and 23 paralogues. Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.1) and 23 other tissues.

功能概要

自然杀伤 (NK) 细胞是淋巴细胞，无需预先激活即可介导某些肿瘤细胞和病毒感染细胞的裂解。它们还可以调节特定的体液免疫和细胞介导的免疫。该基因编码的蛋白属于杀伤细胞凝集素样受体 (KLR) 家族，是一组在 NK 细胞中优先表达的跨膜蛋白。对小鼠的研究表明，该基因的表达可能受 MHC I 类分子的调节。[RefSeq 提供，2016 年 6 月]

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]

KLRG1 基因产物(5)

mRNA Protein Name
NM_001329099.2 NP_001316028.1 killer cell lectin-like receptor subfamily G member 1 isoform a
NM_001329101.2 NP_001316030.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329102.2 NP_001316031.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_001329103.2 NP_001316032.1 killer cell lectin-like receptor subfamily G member 1 isoform c
NM_005810.4 NP_005801.3 killer cell lectin-like receptor subfamily G member 1 isoform b

KLRG1 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (93 - 186)

  • 0
  • 100
  • 195 a.a.
蛋白主名 其他名称

killer cell lectin-like receptor subfamily G member 1

C-type lectin domain family 15 member A

重组 KLRG1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71607 KLRG1 Protein, Human (His-SUMO) Q96E93 (L60-F195) ≥95%

关联疾病

疾病名称 别名
Mastocytosis

Mast Cell Disease

Mast Cell Hyperplasia

Urticaria Pigmentosa

Malignant Mastocytoma

Malignant Mast Cell Tumours

Malignant Mastocytosis
Thyroid Dyshormonogenesis 3

TDH3

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3

Thyroid Hormonogenesis, Genetic Defect In, 3

Genetic Defect In Thyroid Hormonogenesis 3

Chdh3

Congenital Hypothyroidism Due To Dyshormonogenesis Type 3

Genetic Defect In Thyroid Hormonogenesis Type 3
Mast-Cell Leukemia

Mast Cell Leukemia

Leukemia, Mast-Cell

Leukemia Mast Cell

Mast Cell Leukaemia Nos

Mast Cell Leukaemia Without Mention Of Remission
Macular Degeneration, Age-Related, 8

Age Related Macular Degeneration 8

ARMD8

Macular Degeneration, Age-Related, Type 8
Systemic Mastocytosis

Systemic Mast Cell Disease

Systemic Tissue Mast Cell Disease

Mastocytosis, Systemic

Smcd - Systemic Mast Cell Disease

Smcd

Mast Cell Disease, Systemic

Systemic Mast-Cell Disease

Systemic Mastocytoses

Mastocytosis Systemic

Corneal Dystrophy, Subepithelial Mucinous

Smcd - [Systemic Mast Cell Disease]
Listeriosis

Listeria Infection

Infection By Listeria Monocytogenes

Listeria Monocytogenes Infection

Listeria Infections

Listerial Foodborne Infection

Circling Disease

Infection Due To Listeria Monocytogenes

Listerellosis
Dermatitis, Atopic, 5

ATOD5

Atopic Dermatitis 5

Dermatitis, Atopic, Susceptibility To, 5

Dermatitis, Atopic 5
Bronchiectasis 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07397 KLRG1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta KLRG1 VGNC VGNC:74196
Rattus norvegicus KLRG1 RGD RGD:61978
Bos taurus KLRG1 VGNC VGNC:30687
Canis familiaris KLRG1 VGNC VGNC:42487
Mus musculus KLRG1 MGD MGI:1355294
Others KLRG1 NCBI
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