2. Gene
  3. LRRN2 - leucine rich repeat neuronal 2 Gene

LRRN2 - leucine rich repeat neuronal 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富亮氨酸重复神经元 2

种属: Homo sapiens

同用名: GAC1; LRRN5; LRANK1; FIGLER7

基因 ID: 10446 | 基因类型: protein coding

关于 LRRN2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,617,170-204,685,738 (from NCBI)

This gene has 4 transcripts (splice variants), 185 orthologues and 25 paralogues. Broad expression in brain (RPKM 5.5), kidney (RPKM 2.6) and 20 other tissues.

功能概要

该基因编码的蛋白质属于富含亮氨酸的重复超家族。该基因被发现在恶性神经胶质瘤中被放大和过度表达。编码的蛋白质与其他作为细胞粘附分子或信号转导受体的蛋白质具有同源性，是恶性神经胶质瘤 1q32.1 扩增子中靶基因的候选者。已针对该基因描述了编码相同蛋白质的两个可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

LRRN2 基因产物(2)

mRNA Protein Name
NM_006338.3 NP_006329.2 leucine-rich repeat neuronal protein 2 precursor
NM_201630.2 NP_963924.1 leucine-rich repeat neuronal protein 2 precursor

LRRN2 蛋白结构

LRR_6

LRR_6: Leucine Rich repeat (94 - 107)

LRR_8

LRR_8: Leucine rich repeat (117 - 167)

LRR_8

LRR_8: Leucine rich repeat (189 - 249)

LRR_8

LRR_8: Leucine rich repeat (310 - 371)

I-set

I-set: Immunoglobulin I-set domain (430 - 514)

  • 0
  • 200
  • 400
  • 600
  • 713 a.a.
蛋白主名 其他名称

leucine-rich repeat neuronal protein 2

fibronectin type III, immunoglobulin and leucine rich repeat domain 7

重组 LRRN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78982 LRRN2 Protein, Human (CHO, His) O75325 (A19-G630) ≥95%

关联疾病

疾病名称 别名
Tremor, Hereditary Essential, 5

ETM5

Essential Tremor 5

Essential Tremor, Hereditary, 5

Hereditary Essential Tremor 5

Tremor, Hereditary Essential 5

Tremor, Essential Hereditary, Type 5
Tremor, Hereditary Essential, 4

ETM4

Essential Tremor 4

Essential Tremor, Hereditary, 4

Hereditary Essential Tremor 4

Tremor, Hereditary Essential 4

Tremor, Hereditary Essential, Type 4
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07837 LRRN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LRRN2 VGNC VGNC:63311
Bos taurus LRRN2 VGNC VGNC:106808
Mus musculus LRRN2 MGD MGI:106037
Rattus norvegicus LRRN2 RGD RGD:1305482
Canis familiaris LRRN2 VGNC VGNC:42825
Others LRRN2 NCBI
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