2. Gene
  3. SNHG14 - small nucleolar RNA host gene 14 Gene

SNHG14 - small nucleolar RNA host gene 14 Gene

  • 基因
  • 疾病

中文名称：小核仁 RNA 宿主基因 14

种属: Homo sapiens

同用名: 115HG; LNCAT; UBE3A-AS; UBE3AATS; UBE3A-AS1; UBE3A-ATS; NCRNA00214; U-UBE3A-ATS; IC-SNURF-SNRPN

基因 ID: 104472715 | 基因类型: ncRNA

关于 SNHG14

Cytogenetic location: 15q11.2 Genomic coordinates (GRCh38): 15:24,823,608-25,419,462 (from NCBI)

功能概要

该基因位于 Prader-Willi 关键区域内，并产生长的、剪接的父本印记 RNA，该 RNA 在 SNRPN (小核糖核蛋白多肽 N) 和 SNURF 基因共享的共同上游启动子区域内启动。该转录本用作小核仁 RNA、C/D 框 115 和 116 簇的宿主 RNA。这种 RNA 以反义方式延伸到泛素蛋白连接酶 E3A 基因 (UBE3A) 的区域，并且被认为可以调节大脑中 UBE3A 的印记表达。该转录物经历广泛的选择性剪接，并可能在该基因组区域内的多个位置开始和终止。未确定所有拼接形式的全长结构。[RefSeq 提供，2017 年 3 月]

This gene is located within the Prader-Willi critical region and produces a long, spliced paternally-imprinted RNA that initiates within a common upstream promoter region shared by the SNRPN (small nuclear ribonucleoprotein polypeptide N) and SNURF genes. This transcript serves as a host RNA for the small nucleolar RNA, C/D box 115 and 116 clusters. This RNA extends in antisense into the region of the ubiquitin protein Ligase E3A gene (UBE3A), and is thought to regulate imprinted expression of UBE3A in the brain. This transcript undergoes extensive alternative splicing, and may initiate and terminate at multiple locations within this genomic region. The full-length structure of all splice forms is not determined. [provided by RefSeq, Mar 2017]

关联疾病

疾病名称 别名
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma
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