CEL - carboxyl ester lipase Gene

中文名称：羧基酯脂肪酶

种属: Homo sapiens

同用名: BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8

关于 CEL

功能概要

该基因编码的蛋白质是一种糖蛋白，从胰腺分泌到消化道，从泌乳乳腺分泌到人乳中。这种蛋白质的生理作用是参与胆固醇和脂溶性维生素酯的水解和吸收。这种编码的蛋白质促进肠道中大量乳糜微粒的产生。它在血浆中的存在也表明它与胆固醇和氧化脂蛋白相互作用以调节动脉粥样硬化的进展。在胰腺肿瘤细胞中，这种编码的蛋白质被认为被隔离在高尔基体隔室内，可能不会被分泌。该基因在编码区包含可变数量的串联重复 (VNTR) 多态性，可能影响编码蛋白的功能。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in Cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with Cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]