2. Gene
  3. USP16 - ubiquitin specific peptidase 16 Gene

USP16 - ubiquitin specific peptidase 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：泛素特异性肽酶 16

种属: Homo sapiens

同用名: UBPM; UBP-M

基因 ID: 10600 | 基因类型: protein coding

关于 USP16

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:29,024,668-29,054,488 (from NCBI)

This gene has 6 transcripts (splice variants), 209 orthologues and 71 paralogues. Ubiquitous expression in thyroid (RPKM 20.1), testis (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码一种去泛素化酶，该酶在有丝分裂开始时被磷酸化，然后在中期/后期转变时去磷酸化。它可以在体外使 H2A 去泛素化，H2A 是染色质的两种主要泛素化蛋白之一，该蛋白的突变形式显示可阻断细胞分裂。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a deubiquitinating Enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

USP16 基因产物(3)

mRNA Protein Name
NM_001001992.2 NP_001001992.1 ubiquitin carboxyl-terminal hydrolase 16 isoform b
NM_001032410.2 NP_001027582.1 ubiquitin carboxyl-terminal hydrolase 16 isoform a
NM_006447.3 NP_006438.1 ubiquitin carboxyl-terminal hydrolase 16 isoform a

USP16 蛋白结构

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (48 - 125)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (196 - 819)

  • 0
  • 200
  • 400
  • 600
  • 823 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 16

deubiquitinating enzyme 16

关联疾病

疾病名称 别名
Chronic Myelomonocytic Leukemia

Leukemia, Myelomonocytic, Chronic

Cmml

Leukemia Myelomonocytic Chronic

Cmml - [Chronic Myelomonocytic Leukaemia]

Chronic Myelomonocytic Leukaemia Without Mention Of Remission

Chronic Monocytic Leukaemia

Chronic Monocytoid Leukaemia
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15527 USP16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus USP16 VGNC VGNC:66870
Canis familiaris USP16 VGNC VGNC:53051
Rattus norvegicus USP16 RGD RGD:1307192
Mus musculus USP16 MGD MGI:1921362
Bos taurus USP16 VGNC VGNC:52842
Macaca mulatta USP16 VGNC VGNC:78738
Others USP16 NCBI
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