2. Gene
  3. ADCY2 - adenylate cyclase 2 Gene

ADCY2 - adenylate cyclase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腺苷酸环化酶 2

种属: Homo sapiens

同用名: AC2; HBAC2

基因 ID: 108 | 基因类型: protein coding

关于 ADCY2

Cytogenetic location: 5p15.31 Genomic coordinates (GRCh38): 5:7,396,138-7,830,081 (from NCBI)

This gene has 8 transcripts (splice variants), 254 orthologues and 17 paralogues. Biased expression in brain (RPKM 19.2), prostate (RPKM 3.0) and 6 other tissues.

功能概要

该基因编码腺苷酸环化酶家族的一个成员，腺苷酸环化酶是一种膜相关酶，可催化第二信使环磷酸腺苷 (cAMP) 的形成。这种酶对 CA (2+) /钙调蛋白不敏感，并受 G 蛋白 β 和 γ 亚基复合物的刺激。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated Enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to CA(2+)/Calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

ADCY2 基因产物(1)

mRNA Protein Name
NM_020546.3 NP_065433.2 adenylate cyclase type 2
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11549699 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
11549699 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADCY2 蛋白结构

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (282 - 463)

DUF1053

DUF1053: Domain of Unknown Function (DUF1053) (495 - 600)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (879 - 1077)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1091 a.a.
蛋白主名 其他名称

adenylate cyclase type 2

3',5'-cyclic AMP synthetase

关联疾病

疾病名称 别名
Kleine-Levin Hibernation Syndrome

Kleine-Levin Syndrome

Familial Kleine-Levin Syndrome

Kleine Levin Syndrome

Familial Hibernation Syndrome

Recurrent Hypersomnolence

Hypersomnia-Bulimia Syndrome
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00328 ADCY2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21474 Adcy2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27992 Adcy2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ADCY2 VGNC VGNC:59615
Mus musculus ADCY2 MGD MGI:99676
Macaca mulatta ADCY2 VGNC VGNC:69506
Rattus norvegicus ADCY2 RGD RGD:619965
Canis familiaris ADCY2 VGNC VGNC:37619
Bos taurus ADCY2 VGNC VGNC:25643
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