2. Gene
  3. PROKR1 - prokineticin receptor 1 Gene

PROKR1 - prokineticin receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：促动力素受体 1

种属: Homo sapiens

同用名: ZAQ; PKR1; GPR73; PK-R1; GPR73a

基因 ID: 10887 | 基因类型: protein coding

关于 PROKR1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,643,579-68,658,251 (from NCBI)

This gene has 1 transcript (splice variant), 109 orthologues and 33 paralogues. Biased expression in fat (RPKM 1.4), adrenal (RPKM 0.7) and 2 other tissues.

功能概要

该基因编码 G 蛋白偶联受体家族的一个成员。编码的蛋白质与前动力蛋白 (1 和 2) 结合，导致 MAPK 和 STAT 信号通路的激活。前动力蛋白是参与血管生成和炎症的蛋白质配体。编码的蛋白质在外周组织中表达，例如包括循环系统、肺、生殖系统、内分泌系统和胃肠系统的外周组织。在原始卵泡形成开始期间，该蛋白质可能参与人胎儿卵巢中的信号传导。该基因的序列变异可能与反复流产有关。[RefSeq 提供，2016 年 8 月]

This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]

PROKR1 基因产物(1)

mRNA Protein Name
NM_138964.4 NP_620414.1 prokineticin receptor 1

PROKR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (79 - 338)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
蛋白主名 其他名称

prokineticin receptor 1

G protein-coupled receptor 73

关联疾病

疾病名称 别名
Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11196 PROKR1 Human Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990425 Anti-GPR73/PROKR1 Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PROKR1 RGD RGD:708443
Felis catus PROKR1 VGNC VGNC:81157
Macaca mulatta PROKR1 VGNC VGNC:106199
Canis familiaris PROKR1 VGNC VGNC:54534
Mus musculus PROKR1 MGD MGI:1929676
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