2. Gene
  3. DHRS4 - dehydrogenase/reductase 4 Gene

DHRS4 - dehydrogenase/reductase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脱氢酶/还原酶 4

种属: Homo sapiens

同用名: CR; NRDR; PHCR; PSCD; SDR-SRL; SDR25C1; SDR25C2; SCAD-SRL

基因 ID: 10901 | 基因类型: protein coding

关于 DHRS4

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,953,770-23,969,279 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 350 orthologues and 13 paralogues. Broad expression in kidney (RPKM 98.6), small intestine (RPKM 30.5) and 22 other tissues.

功能概要

实现相同的蛋白质结合活性；氧化还原酶活性，作为受体作用于 NAD (P) H、醌或类似化合物；和氧化还原酶活性，作用于供体的 CH-OH 基团，NAD 或 NADP 作为受体。参与多个过程，包括细胞酮代谢过程；积极调节活性氧代谢过程；和类固醇代谢过程。位于细胞核和过氧化物酶体膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including cellular ketone metabolic process; positive regulation of Reactive Oxygen Species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

DHRS4 基因产物(7)

mRNA Protein Name
NM_001282987.2 NP_001269916.1 dehydrogenase/reductase SDR family member 4 isoform 2
NM_001282988.2 NP_001269917.1 dehydrogenase/reductase SDR family member 4 isoform 3
NM_001282989.2 NP_001269918.1 dehydrogenase/reductase SDR family member 4 isoform 4
NM_001282990.2 NP_001269919.1 dehydrogenase/reductase SDR family member 4 isoform 5
NM_001282991.2 NP_001269920.1 dehydrogenase/reductase SDR family member 4 isoform 6
NM_001411004.1 NP_001397933.1 dehydrogenase/reductase SDR family member 4 isoform 7
NM_021004.4 NP_066284.2 dehydrogenase/reductase SDR family member 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-keto sterol reductase activity IDA
IDA: 通过直接分析推断
18571493 GOA
enables alcohol dehydrogenase [NAD(P)+] activity IDA
IDA: 通过直接分析推断
18571493 GOA
enables carbonyl reductase (NADPH) activity IDA
IDA: 通过直接分析推断
18571493 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
18571493 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18571493 GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
IDA: 通过直接分析推断
19442656 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in alcohol metabolic process IDA
IDA: 通过直接分析推断
18571493 GOA
involved in cellular ketone metabolic process IDA
IDA: 通过直接分析推断
18571493 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
19442656 GOA
involved in steroid metabolic process IDA
IDA: 通过直接分析推断
18571493 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
22227495 GOA
located in peroxisomal membrane IDA
IDA: 通过直接分析推断
10333503 GOA
located in peroxisome IDA
IDA: 通过直接分析推断
17230527 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DHRS4 蛋白结构

adh_short_C2

adh_short_C2: Enoyl-(Acyl carrier protein) reductase (41 - 273)

  • 0
  • 100
  • 200
  • 278 a.a.
蛋白主名 其他名称

dehydrogenase/reductase SDR family member 4

NADPH-dependent carbonyl reductase

关联疾病

疾病名称 别名
Subjective Cognitive Decline
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03742 DHRS4 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DHRS4 MGD MGI:90169
Rattus norvegicus DHRS4 RGD RGD:708482
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z