2. Gene
  3. PAPOLA - poly(A) polymerase alpha Gene

PAPOLA - poly(A) polymerase alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (A) 聚合酶α

种属: Homo sapiens

同用名: PAP; PAP-alpha

基因 ID: 10914 | 基因类型: protein coding

关于 PAPOLA

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,502,376-96,567,116 (from NCBI)

This gene has 26 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 27.7), thyroid (RPKM 22.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 poly (A) 聚合酶家族。需要添加腺苷残基来创建 mRNA 的 3'-poly (A) 尾巴。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PAPOLA 基因产物(10)

mRNA Protein Name
NM_001252006.1 NP_001238935.1 poly(A) polymerase alpha isoform 2
NM_001252007.1 NP_001238936.1 poly(A) polymerase alpha isoform 3
NM_001293627.1 NP_001280556.1 poly(A) polymerase alpha isoform 4
NM_001293628.2 NP_001280557.1 poly(A) polymerase alpha isoform 5
NM_001293632.3 NP_001280561.1 poly(A) polymerase alpha isoform 5
NM_001363662.3 NP_001350591.1 poly(A) polymerase alpha isoform 6
NM_001363664.3 NP_001350593.1 poly(A) polymerase alpha isoform 7
NM_001363665.3 NP_001350594.1 poly(A) polymerase alpha isoform 8
NM_001363666.3 NP_001350595.1 poly(A) polymerase alpha isoform 9
NM_032632.5 NP_116021.2 poly(A) polymerase alpha isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables poly(A) RNA polymerase activity IDA
IDA: 通过直接分析推断
7590244 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7590244 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: 通过直接分析推断
19224921 GOA
involved in mRNA 3'-end processing IDA
IDA: 通过直接分析推断
7590244 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PAPOLA 蛋白结构

PAP_central

PAP_central: Poly(A) polymerase central domain (17 - 364)

NTP_transf_2

NTP_transf_2: Nucleotidyltransferase domain (94 - 173)

PAP_RNA-bind

PAP_RNA-bind: Poly(A) polymerase predicted RNA binding domain (366 - 507)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
蛋白主名 其他名称

poly(A) polymerase alpha

polynucleotide adenylyltransferase alpha

关联疾病

疾病名称 别名
46,Xx Sex Reversal 3

SRXX3

Chromosome Xq26 Duplication Syndrome

46,Xx Sex Reversal, Sox3-Related

46xx Sex Reversal 3

46,Xx Male Sex Reversal Sox3-Related
Combat Disorder

Combat Disorders

Combat Neurosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10026 PAPOLA Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PAPOLA VGNC VGNC:80891
Canis familiaris PAPOLA VGNC VGNC:50551
Mus musculus PAPOLA MGD MGI:109301
Rattus norvegicus PAPOLA RGD RGD:1308673
Macaca mulatta PAPOLA VGNC VGNC:84415
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