TMED10 - transmembrane p24 trafficking protein 10 Gene

中文名称：跨膜 p24 运输蛋白 10

种属: Homo sapiens

同用名: p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA)

关于 TMED10

功能概要

该基因是 EMP24/GP25L/p24 家族的成员，编码具有 GOLD 结构域的蛋白质。这种 I 型膜蛋白定位于质膜和高尔基体池，并参与囊泡蛋白运输。该蛋白质也是异聚分泌酶复合体的成员，可调节复合体的 γ-分泌酶活性而不影响其 epsilon-分泌酶活性。该基因的突变与早发性家族性阿尔茨海默病有关。该基因在 8 号染色体上有一个假基因。[RefSeq 提供，2008 年 7 月]

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]