KDELR2 - KDEL endoplasmic reticulum protein retention receptor 2 Gene

中文名称：KDEL 内质网蛋白保留受体 2

种属: Homo sapiens

同用名: ELP1; OI21; ELP-1; ERD2.2

关于 KDELR2

功能概要

通过从顺式高尔基体或前高尔基体隔室中不断回收，在内质网 (ER) 腔内保留常驻可溶性蛋白质是在酵母和动物细胞中实现的。这些蛋白质的分类取决于 C 端四肽信号，通常是动物细胞中的 lys-asp-glu-leu (KDEL) 和酿酒酵母中的 his-asp-glu-leu (HDEL) 。该过程由识别并结合含有四肽的蛋白质并将其返回到 ER 的受体介导。在酵母中，由单个基因 ERD2 编码的分选受体是一种七跨膜蛋白。与酵母不同，已经描述了构成 KDEL 受体基因家族的 ERD2 基因的几种人类同系物。 KDELR2 是该家族中第二个被鉴定的成员，它编码的蛋白质与 KDELR1 基因产物有 83% 的同一性。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]