1. Gene
  2. LILRA3 - leukocyte immunoglobulin like receptor A3 Gene

LILRA3 - leukocyte immunoglobulin like receptor A3 Gene

中文名称:白细胞免疫球蛋白样受体 A3

种属: Homo sapiens

同用名: HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4

基因 ID: 11026 | 基因类型: protein coding

关于 LILRA3

Cytogenetic location: 19q13.4 Genomic coordinates (GRCh38): 19:50,900,001-58,617,616

功能概要

该基因编码免疫受体家族的一个成员,该家族主要在单核细胞和 B 细胞中表达,在树突细胞和自然杀伤细胞中表达水平较低。编码的蛋白质缺乏在该家族其他成员中发现的跨膜区域。它充当 I 类主要组织相容性复合体 (MHC) 抗原的可溶性受体。已发现编码不同亚型的选择性剪接转录物变体。该基因位于 19 号染色体上的一组相关基因中,在人群中具有多态性,许多个体都包含该基因组区域的缺失。[RefSeq 提供,2014 年 3 月]

This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]

LILRA3 基因产物(2)

mRNA Protein Name
NM_001172654.2 NP_001166125.1 leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 2 precursor
NM_006865.4 NP_006856.3 leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1 precursor

LILRA3 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (45 - 135)

Ig_3

Ig_3: Immunoglobulin domain (141 - 216)

Ig_2

Ig_2: Immunoglobulin domain (242 - 334)

Ig_3

Ig_3: Immunoglobulin domain (343 - 417)

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  • 456 a.a.
蛋白主名 其他名称

leukocyte immunoglobulin-like receptor subfamily A member 3

CD85 antigen-like family member E

重组 LILRA3 蛋白