LILRA2 - leukocyte immunoglobulin like receptor A2 Gene

中文名称：白细胞免疫球蛋白样受体 A2

种属: Homo sapiens

同用名: ILT1; LIR7; CD85H; LIR-7

关于 LILRA2

功能概要

该基因编码免疫受体家族的一个成员，该家族主要在单核细胞和 B 细胞上表达，在树突细胞和自然杀伤细胞上表达水平较低。编码的蛋白质是一种激活受体，可抑制树突状细胞分化和抗原呈递，并抑制先天免疫反应。已发现编码不同亚型的选择性剪接转录物变体。该基因位于 19 号染色体上的一组相关基因中，并且该基因在 3 号染色体上有一个假基因。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014]