2. Gene
  3. Chrna3 - cholinergic receptor, nicotinic, alpha polypeptide 3 Gene

Chrna3 - cholinergic receptor, nicotinic, alpha polypeptide 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: (a)3; Acra3; Acra-3; A730007P14Rik

基因 ID: 110834 | 基因类型: protein coding

关于 Chrna3

功能概要

Enables acetylcholine-gated cation-selective channel activity. Acts upstream of or within several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Is integral component of postsynaptic specialization membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in lung Cancer. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). [provided by Alliance of Genome Resources, Apr 2022]

Chrna3 基因产物(1)

mRNA Protein Name
NM_145129.3 NP_660111.3 neuronal acetylcholine receptor subunit alpha-3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: 通过突变表型推断
11923417 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19474315 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: 通过直接分析推断
16162937 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: 通过突变表型推断
16162937 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within activation of transmembrane receptor protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
16162937 MGI
acts upstream of or within behavioral response to nicotine IMP
IMP: 通过突变表型推断
15275829 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
16162937 MGI
acts upstream of or within locomotory behavior IMP
IMP: 通过突变表型推断
15275829 MGI
acts upstream of or within regulation of acetylcholine secretion, neurotransmission IMP
IMP: 通过突变表型推断
16162937 MGI
acts upstream of or within regulation of dendrite morphogenesis IMP
IMP: 通过突变表型推断
11027228 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
10318955 MGI
acts upstream of or within regulation of muscle contraction IMP
IMP: 通过突变表型推断
10318955 MGI
acts upstream of or within regulation of smooth muscle contraction IMP
IMP: 通过突变表型推断
10318955 MGI
acts upstream of or within synaptic transmission involved in micturition IMP
IMP: 通过突变表型推断
10771006 MGI
acts upstream of or within synaptic transmission, cholinergic IMP
IMP: 通过突变表型推断
16162937 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of acetylcholine-gated channel complex IPI
IPI: 通过物理相互作用推断
17434683 MGI
is active in cholinergic synapse IDA
IDA: 通过直接分析推断
12079404 MGI
is active in cholinergic synapse IMP
IMP: 通过突变表型推断
16162937 MGI
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
12079404 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neuronal acetylcholine receptor subunit alpha-3

alpha 3

neuronal nicotinic acetylcholine receptor, alpha 3 subunit

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02668 CHRNA3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20143 Chrna3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26647 Chrna3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chrna3 NCBI NCBI:1136
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