ADAMTS8 - ADAM metallopeptidase with thrombospondin type 1 motif 8 Gene

中文名称：具有 1 型血小板反应蛋白基序 8 的 ADAM 金属肽酶

种属: Homo sapiens

同用名: METH2; ADAM-TS8

关于 ADAMTS8

功能概要

该基因编码 ADAMTS (一种具有血小板反应蛋白基序的去整合素和金属蛋白酶) 蛋白家族的成员。该家族的成员共享几个不同的蛋白质模块，包括前肽区域、金属蛋白酶结构域、解整合素样结构域和 1 型血小板反应蛋白 (TS) 基序。这个家族的个别成员在 C 端 TS 基序的数量上有所不同，有些成员具有独特的 C 端结构域。编码的前原蛋白经过蛋白水解处理以产生成熟酶。该酶包含两个 C 末端 TS 基序，并破坏体内的血管生成。许多疾病已被定位在该基因附近，最显着的是肺肿瘤。已在多种人类癌症中观察到该基因的表达减少，并且该基因已被提议作为潜在的肿瘤抑制因子。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]