2. Gene
  3. PWP1 - PWP1 homolog, endonuclein Gene

PWP1 - PWP1 homolog, endonuclein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PWP1 同源物，内切核蛋白

种属: Homo sapiens

同用名: NCLB; IEF-SSP-9502

基因 ID: 11137 | 基因类型: protein coding

关于 PWP1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:107,685,799-107,713,162 (from NCBI)

This gene has 5 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 14.1), brain (RPKM 13.4) and 25 other tissues.

功能概要

该基因编码的蛋白质包含多个 WD-40 重复序列，主要存在于细胞核中。该蛋白的表达和定位依赖于细胞周期。该基因的表达在胰腺癌中上调。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

PWP1 基因产物(3)

mRNA Protein Name
NM_001317962.2 NP_001304891.1 periodic tryptophan protein 1 homolog isoform 2
NM_001317963.2 NP_001304892.1 periodic tryptophan protein 1 homolog isoform 3
NM_007062.3 NP_008993.1 periodic tryptophan protein 1 homolog isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
IDA: 通过直接分析推断
29065309 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
29065309 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PWP1 蛋白结构

WD40

WD40: WD domain, G-beta repeat (253 - 285)

WD40

WD40: WD domain, G-beta repeat (290 - 328)

WD40

WD40: WD domain, G-beta repeat (376 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
蛋白主名 其他名称

periodic tryptophan protein 1 homolog

endonuclein

PWP1 抗体

目录号 产品名 应用 反应物种
HY-P82039 PWP1 Antibody (YA1784) WB Human

关联疾病

疾病名称 别名
Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11475 PWP1 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PWP1 VGNC VGNC:45215
Bos taurus PWP1 VGNC VGNC:33580
Felis catus PWP1 VGNC VGNC:64442
Mus musculus PWP1 MGD MGI:1914735
Rattus norvegicus PWP1 RGD RGD:1310705
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z