2. Gene
  3. NUDT6 - nudix hydrolase 6 Gene

NUDT6 - nudix hydrolase 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：nudix 水解酶 6

种属: Homo sapiens

同用名: GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS

基因 ID: 11162 | 基因类型: protein coding

关于 NUDT6

Cytogenetic location: 4q28.1 Genomic coordinates (GRCh38): 4:122,892,577-122,922,968 (from NCBI)

This gene has 8 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in fat (RPKM 12.5), kidney (RPKM 8.8) and 23 other tissues.

功能概要

该基因与 FGF2 基因重叠并位于相反链上，被认为是 FGF2 反义基因。这两个基因是独立转录的，它们的表达呈反比关系，表明该反义转录本可能调节 FGF2 的表达。该基因还显示在垂体中具有独立于 FGF2 表达的激素调节和抗增殖作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NUDT6 基因产物(2)

mRNA Protein Name
NM_007083.5 NP_009014.2 nucleoside diphosphate-linked moiety X motif 6 isoform a
NM_198041.3 NP_932158.1 nucleoside diphosphate-linked moiety X motif 6 isoform b
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell cycle IDA
IDA: 通过直接分析推断
11266510 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11266510 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11266510 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUDT6 蛋白结构

NUDIX

NUDIX: NUDIX domain (143 - 265)

  • 0
  • 100
  • 200
  • 316 a.a.
蛋白主名 其他名称

nucleoside diphosphate-linked moiety X motif 6

antisense basic fibroblast growth factor

关联疾病

疾病名称 别名
Desmoid Disease, Hereditary

Fif

DESMD

Hereditary Desmoid Disease

Familial Infiltrative Fibromatosis

Fibromatosis, Familial Infiltrative

Fibromatosis, Aggressive
Gingival Overgrowth

Gingival Enlargement

Gingival Hyperplasia

Gingival Bulge

Gingival Enlargement Nos

Gingival Hypertrophy

Gum Hypertrophy

Hyperplasia Gum

Gingival Thickening

Hyperplasia Of Gingiva

Hypertrophy Of Gingiva

Hypertrophy Of Mucous Membrane Of Gums
Central Neurocytoma

Neurocytoma

Neurolipocytoma

Neurocytoma Central
Gastric Ulcer

Stomach Ulcer

Acute Gastric Ulcer With Haemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

Acute Gastric Ulcer With Hemorrhage, With Obstruction

Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

Acute Gastric Ulcer With Perforation

Acute Gastric Ulcer With Perforation And Obstruction

Acute Gastric Ulcer With Perforation, With Obstruction

Acute Gastric Ulcer Without Hemorrhage And Without Perforation

Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

Bleeding Acute Gastric Ulcer

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

Gastric Ulcers

Cushings Ulcer

Cushing'S Ulcer Of Stomach

Peptic Ulcer Of Stomach

Mucosal Defect Of The Stomach
Glioma
Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia
Cartilage Cancer

Chondrogenic Neoplasm
Retinal Degeneration

Degeneration Of Retina
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09674 NUDT6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NUDT6 RGD RGD:621356
Bos taurus NUDT6 VGNC VGNC:32340
Felis catus NUDT6 VGNC VGNC:78540
Macaca mulatta NUDT6 VGNC VGNC:75553
Mus musculus NUDT6 MGD MGI:2387618
Canis familiaris NUDT6 VGNC VGNC:54811
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