AKAP10 - A-kinase anchoring protein 10 Gene

中文名称：A-激酶锚定蛋白 10

种属: Homo sapiens

同用名: PRKA10; AKAP-10; D-AKAP2; D-AKAP-2

关于 AKAP10

功能概要

该基因编码 A 激酶锚定蛋白家族的一个成员。 A-激酶锚定蛋白与蛋白激酶 A (PKA) 的调节亚基结合，并将全酶限制在细胞内的离散位置。编码的蛋白质定位于线粒体，并与 PKA 的 I 型和 II 型调节亚基相互作用。该基因的多态性可能与心律失常和心源性猝死的风险增加有关。[RefSeq 提供，2012 年 5 月]

This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012]