2. Gene
  3. Egln1 - egl-9 family hypoxia-inducible factor 1 Gene

Egln1 - egl-9 family hypoxia-inducible factor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Phd2; HPH-2; ORF13; SM-20; C1orf12; HIF-PH2; Hif-p4h-2

基因 ID: 112405 | 基因类型: protein coding

关于 Egln1

功能概要

Predicted to enable enzyme binding activity; ferrous iron binding activity; and peptidyl-proline 4-dioxygenase activity. Involved in several processes, including cellular iron ion homeostasis; regulation of angiogenesis; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Acts upstream of or within heart morphogenesis and labyrinthine layer development. Located in glutamatergic synapse. Is active in postsynaptic density. Is expressed in brain; genitourinary system; and trunk. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Egln1 基因产物(2)

mRNA Protein Name
NM_001363475.2 NP_001350404.1 egl nine homolog 1 isoform 2
NM_053207.3 NP_444437.2 egl nine homolog 1 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
16966370 MGI
acts upstream of or within heart trabecula formation IMP
IMP: 通过突变表型推断
16966370 MGI
involved in intracellular iron ion homeostasis IMP
IMP: 通过突变表型推断
26818499 MGI
acts upstream of or within labyrinthine layer development IMP
IMP: 通过突变表型推断
16966370 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
26818499 MGI
involved in regulation of angiogenesis IMP
IMP: 通过突变表型推断
18500250 MGI
involved in regulation of modification of postsynaptic structure IDA
IDA: 通过直接分析推断
26972007 MGI
involved in regulation of modification of postsynaptic structure IEP
IEP: 通过表达模式推断
26972007 MGI
involved in regulation of modification of postsynaptic structure IMP
IMP: 通过突变表型推断
26972007 MGI
involved in regulation protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
26972007 MGI
involved in regulation protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
26972007 MGI
involved in regulation protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
26972007 MGI
acts upstream of or within ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
16966370 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26972007 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
26972007 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
26972007 MGI
is active in postsynaptic density IDA
IDA: 通过直接分析推断
26972007 MGI
is active in postsynaptic density IEP
IEP: 通过表达模式推断
26972007 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

egl nine homolog 1

HIF-prolyl hydroxylase 2

hypoxia-inducible factor prolyl hydroxylase 2

prolyl hydroxylase domain-containing protein 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04212 EGLN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18812 Egln1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25302 Egln1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Egln1 NCBI NCBI:54583
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