KLF8 - KLF transcription factor 8 Gene

中文名称：KLF 转录因子 8

种属: Homo sapiens

同用名: BKLF3; ZNF741

关于 KLF8

功能概要

该基因编码的蛋白质是 Sp/KLF 转录因子家族的成员。该家族的成员包含一个带有三个 Kruppel 样锌指的 C 端 DNA 结合域。编码的蛋白质被认为在调节上皮到间充质转化中发挥重要作用，这一过程通常发生在发育过程中，但也会发生在转移过程中。已在 16 号染色体上鉴定出一个假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 4 月]

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]