1. Gene
  2. GOLM2 - golgi membrane protein 2 Gene

GOLM2 - golgi membrane protein 2 Gene

中文名称:高尔基体膜蛋白 2

种属: Homo sapiens

同用名: H63; CASC4

基因 ID: 113201 | 基因类型: protein coding

关于 GOLM2

This gene has 12 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 38.2), adrenal (RPKM 35.0) and 25 other tissues.

功能概要

该基因表达水平的增加与 HER-2/neu 原癌基因的过度表达有关。在大约 30% 的人类乳腺癌和 20% 的人类卵巢癌中发现了这种原癌基因的扩增和由此产生的过度表达。已经为该基因鉴定了编码不同亚型的可变剪接变体。[RefSeq 提供,2010 年 12 月]

The increased expression level of this gene is associated with HER-2/neu proto-oncogene overexpression. Amplification and resulting overexpression of this proto-oncogene are found in approximately 30% of human breast and 20% of human ovarian cancers. Alternatively spliced variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]

GOLM2 基因产物(2)

mRNA Protein Name
NM_138423.4 NP_612432.2 protein GOLM2 isoform a
NM_177974.3 NP_816929.1 protein GOLM2 isoform b
蛋白主名 其他名称

protein GOLM2

cancer susceptibility 4

关联疾病

疾病名称 别名
Schizophrenia 5

SCZD5

Schizophrenia Susceptibility Locus, Chromosome 6q-Related

Schizophrenia 5 With Or Without An Affective Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GOLM2 VGNC VGNC:99200
Mus musculus GOLM2 MGD MGI:2443129
Bos taurus GOLM2 VGNC VGNC:84818
Rattus norvegicus GOLM2 RGD RGD:1305985
Felis catus GOLM2 VGNC VGNC:84871
Canis familiaris GOLM2 VGNC VGNC:84817