2. Gene
  3. Dag1 - dystroglycan 1 Gene

Dag1 - dystroglycan 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 114489 | 基因类型: protein coding

关于 Dag1

功能概要

Enables laminin-1 binding activity. Involved in several processes, including calcium-dependent cell-matrix adhesion; cellular response to cholesterol; and nervous system development. Located in several cellular components, including basolateral plasma membrane; costamere; and focal adhesion. Part of dystrophin-associated glycoprotein complex. Is active in glutamatergic synapse and postsynaptic cytosol. Used to study myocardial infarction. Biomarker of muscular atrophy; primary biliary cholangitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1). [provided by Alliance of Genome Resources, Apr 2022]

Dag1 基因产物(1)

mRNA Protein Name
NM_053697.1 NP_446149.1 dystroglycan precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables laminin binding IDA
IDA: 通过直接分析推断
8996823 RGD
enables laminin-1 binding IDA
IDA: 通过直接分析推断
9153251 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15247274 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Schwann cell differentiation IEP
IEP: 通过表达模式推断
11869039 RGD
involved in angiogenesis involved in wound healing IEP
IEP: 通过表达模式推断
21192954 RGD
involved in axon regeneration IEP
IEP: 通过表达模式推断
16228655 RGD
involved in calcium-dependent cell-matrix adhesion IMP
IMP: 通过突变表型推断
12177244 RGD
involved in cellular response to cholesterol IEP
IEP: 通过表达模式推断
22613990 RGD
involved in cellular response to mechanical stimulus IMP
IMP: 通过突变表型推断
18556591 RGD
involved in nerve development IEP
IEP: 通过表达模式推断
16228655 RGD
involved in positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
9153251 RGD
involved in positive regulation of myelination IMP
IMP: 通过突变表型推断
17395644 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
17395644 RGD
involved in positive regulation of protein kinase activity IMP
IMP: 通过突变表型推断
18556591 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: 通过表达模式推断
8906620 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
11416038 RGD
involved in skeletal muscle tissue regeneration IEP
IEP: 通过表达模式推断
12086334 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
9117347 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11416038 RGD
located in costamere IDA
IDA: 通过直接分析推断
10531619 RGD
part of dystrophin-associated glycoprotein complex IDA
IDA: 通过直接分析推断
15247274 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
9153251 RGD
located in focal adhesion IDA
IDA: 通过直接分析推断
9117347 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
9446825 RGD
located in nuclear periphery IDA
IDA: 通过直接分析推断
21668890 RGD
located in plasma membrane raft IDA
IDA: 通过直接分析推断
22613990 RGD
is active in postsynaptic cytosol IDA
IDA: 通过直接分析推断
9446825 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
10531619 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dystroglycan

alpha-dystroglycan

beta-dystroglycan

dystroglycan 1 (dystrophin-associated glycoprotein 1)

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-131897 1-Stearoyl-2-arachidonoyl-sn-glycerol Activator ≥99.0% 否
HY-W100403 Choline tosylate Inhibitor 99.41% 否
HY-131897S 1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol Activator / 否
HY-RS03519 DAG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS18922 Dag1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS25412 Dag1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dag1 NCBI NCBI:1605
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