2. Gene
  3. CARD16 - caspase recruitment domain family member 16 Gene

CARD16 - caspase recruitment domain family member 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：胱天蛋白酶招募域家族成员 16

种属: Homo sapiens

同用名: COP; COP1; PSEUDO-ICE; LLID-114769

基因 ID: 114769 | 基因类型: protein coding

关于 CARD16

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:105,041,563-105,045,335 (from NCBI)

This gene has 5 transcripts (splice variants), 424 orthologues and 16 paralogues. Broad expression in spleen (RPKM 14.0), appendix (RPKM 12.0) and 23 other tissues.

功能概要

启用多项功能，包括 CARD 域绑定活动；半胱氨酸型内肽酶抑制剂活性；和酶结合活性。参与多个过程，包括半胱氨酸型内肽酶活性的负调节；基因表达的调节；和信号转导的调节。蛋白酶抑制剂复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including CARD domain binding activity; cysteine-type endopeptidase inhibitor activity; and enzyme binding activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of signal transduction. Part of protease inhibitor complex. [provided by Alliance of Genome Resources, Apr 2022]

CARD16 基因产物(2)

mRNA Protein Name
NM_001394580.1 NP_001381509.1 caspase recruitment domain-containing protein 16 isoform 3
NM_052889.4 NP_443121.1 caspase recruitment domain-containing protein 16 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CARD domain binding IPI
IPI: 通过物理相互作用推断
11821383 GOA
enables caspase binding IPI
IPI: 通过物理相互作用推断
11432859 GOA
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
16920334 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
11432859 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
11432859 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11536016 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
15383541 GOA
involved in inhibition of cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
11432859 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16920334 GOA
involved in negative regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
11432859 GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway IDA
IDA: 通过直接分析推断
11432859 GOA
involved in negative regulation of protein binding IDA
IDA: 通过直接分析推断
11432859 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
16920334 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
11536016 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
15383541 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protease inhibitor complex IDA
IDA: 通过直接分析推断
11432859 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
11536016 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CARD16 蛋白结构

CARD

CARD: Caspase recruitment domain (4 - 89)

  • 0
  • 100
  • 197 a.a.
蛋白主名 其他名称

caspase recruitment domain-containing protein 16

CARD only domain-containing protein 1

关联疾病

疾病名称 别名
Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases

Acoustic Nerve Disease

Cochlear Nerve Diseases

Disturbance Of Vestibulocochlear Nerve

Auditory Nerve Disorder

Disorder Of Acoustovestibular Nerve

Disorder Of Eighth Nerve

Eighth Cranial Nerve Disorder

Disease Of Eighth Cranial Nerve

Disease Of Acoustic Nerve

Disease Of Auditory Nerve

Disorder Of 8th Cranial Nerve

Auditory Nerve Lesion

Cochlear Nerve Disorder
Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis
Colon Sarcoma

Colonic Sarcoma
Ehlers-Danlos Syndrome, Hypermobility Type

Ehlers-Danlos Syndrome, Type 3

Ehlers-Danlos Syndrome, Type Iii

EDSHMB

Eds Iii

Benign Hypermobility Syndrome

Ehlers-Danlos Syndrome Hypermobility Type

Eds3

Type Iii Ehlers-Danlos Syndrome

Ehlers-Danlos Syndrome Type 3

Es-D3
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01918 CARD16 Human Pre-designed siRNA Set A Pre-designed Set / 否
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