2. Gene
  3. Adamts1 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 Gene

Adamts1 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1

基因 ID: 11504 | 基因类型: protein coding

关于 Adamts1

功能概要

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast Cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]

Adamts1 基因产物(1)

mRNA Protein Name
NM_009621.5 NP_033751.3 A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparin binding IDA
IDA: 通过直接分析推断
8995297 MGI
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
16061471 MGI
enables metalloendopeptidase activity IMP
IMP: 通过突变表型推断
16061471 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16061471 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within heart trabecula formation IMP
IMP: 通过突变表型推断
18267097 MGI
acts upstream of or within kidney development IMP
IMP: 通过突变表型推断
14668204 MGI
acts upstream of or within ovulation from ovarian follicle IMP
IMP: 通过突变表型推断
14668204 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
16061471 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
12907688 MGI
located in extracellular matrix IDA
IDA: 通过直接分析推断
9593739 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

A disintegrin and metalloproteinase with thrombospondin motifs 1

ADAM-TS 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00291 ADAMTS1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18432 Adamts5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19084 Adamts1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25574 Adamts1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adamts1 NCBI NCBI:9510
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