1. Gene
  2. NXNL1 - nucleoredoxin like 1 Gene

NXNL1 - nucleoredoxin like 1 Gene

中文名称:核氧还蛋白 1

种属: Homo sapiens


基因 ID: 115861 | 基因类型: protein coding

关于 NXNL1

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,455,425-17,460,926 (from NCBI)

This gene has 1 transcript (splice variant), 218 orthologues and 2 paralogues. Biased expression in fat (RPKM 1.0) and adrenal (RPKM 0.2).


视网膜色素变性 (RP) 是一种因视锥光感受器退化而导致失明的疾病。杆产生锥体生存所需的因子。由该基因编码的蛋白质是这些因素之一,类似于硫氧还蛋白的截短形式。该基因已被提议具有治疗 RP 的价值。[RefSeq 提供,2015 年 12 月]

Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. [provided by RefSeq, Dec 2015]

NXNL1 基因产物(1)

mRNA Protein Name
NM_138454.2 NP_612463.1 nucleoredoxin-like protein 1

NXNL1 蛋白结构


Thioredoxin_8: Thioredoxin-like (32 - 132)

  • 0
  • 100
  • 200
  • 212 a.a.
蛋白主名 其他名称

nucleoredoxin-like protein 1

rod-derived cone viability factor


疾病名称 别名
Acquired Color Blindness

Acquired Color Vision Deficiencies

Acquired Color Vision Deficiency

Acquired Colour Blindness

Acquired Colour Vision Deficiencies

Acquired Colour Vision Deficiency

Retinitis Pigmentosa


Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration


Retinitis Pigmentosa Autosomal Recessive


Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Bardet-Biedl Syndrome


Biedl-Bardet Syndrome

Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1


Senile Macular Degeneration

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy



Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2

Eye Degenerative Disease
Cone Dystrophy

Retinal Cone Dystrophy

Dystrophy, Cone

Cone Dystrophy 3

Leber Congenital Amaurosis 1


Amaurosis Congenita Of Leber I


Retinal Blindness, Congenital


Leber Congenital Amaurosis Type I

Leber Congenital Amaurosis, Type 1

Amaurosis Congenita Of Leber, Type 1



Rod Monochromatism

Total Color Blindness

Rod Monochromacy



Complete Or Incomplete Color Blindness

Pingelapese Blindness

Achromatopsia 1

Achromatopsia 2

Achromatopsia 3

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital

Stargardt Disease

Stargardt Disease 1

Stargardt Macular Dystrophy

Stargardt Disease-1

Juvenile Onset Macular Degeneration

Stargardt Macular Degeneration

Juvenile Macular Degeneration

Macular Dystrophy With Flecks, Type 1


Fundus Flavimaculatus

Stargardt 1

Stargardts Disease

Leber Plus Disease

Leber Congenital Amaurosis


Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness


Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia


Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome

Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

Graefe-Usher Syndrome

Hallgren Syndrome

Usher'S Syndrome

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa-Hearing Loss Syndrome


Usher Syndromes

Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy


Cone-Rod Retinal Dystrophy


Cone-Rod Retinal Dystrophy 2




Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy

Eye Disease

Eye Diseases

Abnormality Of The Eye

Toxoplasma Oculopathy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Mus musculus NXNL1 MGD MGI:1924446
Rattus norvegicus NXNL1 RGD RGD:1308296
Canis familiaris NXNL1 VGNC VGNC:44074
Bos taurus NXNL1 VGNC VGNC:32377
Felis catus NXNL1 VGNC VGNC:63936