2. Gene
  3. Lpar1 - lysophosphatidic acid receptor 1 Gene

Lpar1 - lysophosphatidic acid receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酸受体 1

种属: Rattus norvegicus

同用名: Edg2

基因 ID: 116744 | 基因类型: protein coding

关于 Lpar1

Primary_assembly 5: 73,229,625-73,369,895 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 216 orthologues, 18 paralogues and is associated with 15 phenotypes. Biased expression in Brain (RPKM 71.1), Uterus (RPKM 44.2) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白 α 亚基结合活性和磷脂结合活性。参与多个过程，包括细胞对 1-油酰-sn-甘油 3-磷酸的反应；负调节 cAMP 介导的信号；和神经系统发育。位于多个细胞成分中，包括树突；神经细胞体；和质膜。用于研究肝细胞癌和短暂性脑缺血。与人类 LPAR1（溶血磷脂酸受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in several processes, including cellular response to 1-oleoyl-sn-glycerol 3-phosphate; negative regulation of cAMP-mediated signaling; and nervous system development. Located in several cellular components, including dendrite; neuronal cell body; and plasma membrane. Used to study hepatocellular carcinoma and transient cerebral ischemia. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpar1 基因产物(1)

mRNA Protein Name
NM_053936.4 NP_446388.1 lysophosphatidic acid receptor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-protein alpha-subunit binding IMP
IMP: 通过突变表型推断
16504475 RGD
enables phospholipid binding IMP
IMP: 通过突变表型推断
16504475 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
16504475 RGD
involved in cellular response to 1-oleoyl-sn-glycerol 3-phosphate IMP
IMP: 通过突变表型推断
12139919 RGD
involved in cellular response to oxygen levels IEP
IEP: 通过表达模式推断
18978343 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
9753172 RGD
involved in corpus callosum development IEP
IEP: 通过表达模式推断
9753172 RGD
involved in myelination IEP
IEP: 通过表达模式推断
10384882 RGD
involved in negative regulation of cAMP/PKA signal transduction IMP
IMP: 通过突变表型推断
12139919 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
18978343 RGD
involved in neurogenesis IEP
IEP: 通过表达模式推断
9753172 RGD
involved in oligodendrocyte development IEP
IEP: 通过表达模式推断
11948806 RGD
involved in optic nerve development IEP
IEP: 通过表达模式推断
12139919 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
16890224 RGD
involved in positive regulation of dendritic spine development IDA
IDA: 通过直接分析推断
16638019 RGD
involved in positive regulation of smooth muscle cell chemotaxis IMP
IMP: 通过突变表型推断
19742132 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: 通过实验结果推断
25996636 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
25996636 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: 通过表达模式推断
25996636 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
25996636 RGD
involved in regulation of synaptic vesicle cycle EXP
EXP: 通过实验结果推断
25996636 RGD
involved in regulation of synaptic vesicle cycle IDA
IDA: 通过直接分析推断
25996636 RGD
involved in regulation of synaptic vesicle cycle IEP
IEP: 通过表达模式推断
25996636 RGD
involved in regulation of synaptic vesicle cycle IMP
IMP: 通过突变表型推断
25996636 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
25996636 RGD
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
25996636 RGD
is active in GABA-ergic synapse IMP
IMP: 通过突变表型推断
25996636 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
16638019 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
16638019 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
25996636 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25996636 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
25996636 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
11948806 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
25996636 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
25996636 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Lpar1 蛋白结构

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (49 - 321)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (50 - 76)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (83 - 108)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (120 - 150)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (161 - 181)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (201 - 230)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (250 - 280)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (289 - 314)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

lysophosphatidic acid receptor 1

LPA receptor 1

LPA-1

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2

lysophosphatidic acid receptor Edg-2

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16039 AM095 Antagonist 99.72% 否
HY-15706 H2L 5765834 Antagonist 98.66% 否
HY-117444 ONO-9780307 Inhibitor 99.94% 否
HY-115450 ONO-0300302 Antagonist 99.43% 否
HY-117959 TAK-615 Inhibitor 98.97% 否
HY-124072 HL001 Antagonist 98.90% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lpar1 NCBI NCBI:1902
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