ARAP2 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 Gene

中文名称：具有 RhoGAP 结构域、锚蛋白重复序列和 PH 结构域 2 的 ArfGAP

种属: Homo sapiens

同用名: PARX; CENTD1

关于 ARAP2

功能概要

该基因编码的蛋白质包含 ARF-GAP、RHO-GAP、锚蛋白重复序列、RAS 相关和 pleckstrin 同源结构域。该蛋白质是一种磷脂酰肌醇 (3,4,5) -三磷酸依赖性 Arf6 GAP，可结合 RhoA-GTP，但它在 RHO-GAP 结构域中缺乏预测的催化精氨酸，并且不具有 RHO-GAP 活性。该蛋白质与 RhoA 下游的粘着斑和功能相关联，以调节粘着斑动力学。[RefSeq 提供，2008 年 9 月]

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]