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  2. Ccr3 - C-C motif chemokine receptor 3 Gene

Ccr3 - C-C motif chemokine receptor 3 Gene

中文名称:CC 基序趋化因子受体 3

种属: Rattus norvegicus

同用名: Cmkbr3

基因 ID: 117027 | 基因类型: protein coding

关于 Ccr3

Primary_assembly 8: 123,616,236-123,634,990 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 142 orthologues, 24 paralogues and is associated with 40 phenotypes. Biased expression in Spleen (RPKM 24.1) and Uterus (RPKM 12.4).

功能概要

预测该基因编码的蛋白可启动 CC 趋化因子结合活性和 CC 趋化因子受体活性。参与 ERK1ERK2 级联;成血管细胞迁移;和白细胞趋化性。位于核内体;细胞外空间;和质膜。用于研究哮喘和心肌梗塞。鼻炎的生物标志物。与哮喘有关的该基因的人类直系同源物;卵巢上皮癌;和鼻炎。与人 CCR3(CC 基序趋化因子受体 3)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Involved in ERK1 and ERK2 cascade; angioblast cell migration; and leukocyte chemotaxis. Located in endosome; extracellular space; and plasma membrane. Used to study asthma and myocardial infarction. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif Chemokine Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ccr3 基因产物(1)

mRNA Protein Name
NM_053958.2 NP_446410.1 C-C chemokine receptor type 3
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
12413953 RGD
involved in angioblast cell migration IMP
IMP: 通过突变表型推断
18954648 RGD
involved in eosinophil chemotaxis IMP
IMP: 通过突变表型推断
16978084 RGD
involved in mast cell chemotaxis IMP
IMP: 通过突变表型推断
12413953 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endosome IDA
IDA: 通过直接分析推断
12004163 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
12004163 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ccr3 蛋白结构

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 315)

7tmA_CCR3

7tmA_CCR3: cd15185 (38 - 65)

7tmA_CCR3

7tmA_CCR3: cd15185 (72 - 97)

7tmA_CCR3

7tmA_CCR3: cd15185 (109 - 139)

7tmA_CCR3

7tmA_CCR3: cd15185 (151 - 173)

7tmA_CCR3

7tmA_CCR3: cd15185 (199 - 228)

7tmA_CCR3

7tmA_CCR3: cd15185 (235 - 265)

7tmA_CCR3

7tmA_CCR3: cd15185 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
蛋白主名 其他名称

C-C chemokine receptor type 3

C-C CKR-3

CC-CKR-3

CCR-3

CKR3

chemokine (C-C motif) receptor 3

chemokine (C-C) receptor 3

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccr3 NCBI NCBI:1232