Mmp12 - matrix metallopeptidase 12 Gene

中文名称：基质金属肽酶 12

种属: Rattus norvegicus

同用名: Mme

关于 Mmp12

功能概要

预计该基因编码的蛋白具有多种功能，包括核心启动子序列特异性 DNA 结合活性；金属离子结合活性；和金属内肽酶活性。参与多个过程，包括上皮细胞增殖的正调节；滋养层细胞迁移的调节；和对缺氧的反应。预计位于细胞质中；细胞外空间；和核。用于研究新月体性肾小球肾炎。抗基底膜肾小球肾炎和新月体性肾小球肾炎的生物标志物。该基因的人类直系同源物与 Barrett 食管有关；动脉疾病（多发性）；冠状动脉瘤；食道腺癌；和多发性硬化症。与人 MMP12（基质金属肽酶 12）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including core promoter sequence-specific DNA binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in several processes, including positive regulation of epithelial cell proliferation; regulation of trophoblast cell migration; and response to hypoxia. Predicted to be located in cytoplasm; extracellular space; and nucleus. Used to study crescentic glomerulonephritis. Biomarker of anti-basement membrane glomerulonephritis and crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in Barrett's esophagus; artery disease (multiple); coronary aneurysm; esophagus adenocarcinoma; and multiple sclerosis. Orthologous to human MMP12 (matrix metallopeptidase 12). [provided by Alliance of Genome Resources, Apr 2022]