2. Gene
  3. MRGPRX2 - MAS related GPR family member X2 Gene

MRGPRX2 - MAS related GPR family member X2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAS 相关 GPR 家族成员 X2

种属: Homo sapiens

同用名: MGRG3; MRGX2

基因 ID: 117194 | 基因类型: protein coding

关于 MRGPRX2

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,054,455-19,060,717 (from NCBI)

This gene has 1 transcript (splice variant), 435 orthologues and 10 paralogues. Low expression observed in reference dataset.

功能概要

启用 G 蛋白偶联受体活性和神经肽结合活性。参与肥大细胞脱颗粒和胞质分裂的正调节。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity and neuropeptide binding activity. Involved in mast cell degranulation and positive regulation of cytokinesis. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

MRGPRX2 基因产物(2)

mRNA Protein Name
NM_001303615.2 NP_001290544.1 mas-related G-protein coupled receptor member X2
NM_054030.4 NP_473371.1 mas-related G-protein coupled receptor member X2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
12915402 GOA
enables neuropeptide binding IPI
IPI: 通过物理相互作用推断
12915402 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mast cell activation IDA
IDA: 通过直接分析推断
25517090 GOA
involved in mast cell degranulation IDA
IDA: 通过直接分析推断
22069323 GOA
involved in positive regulation of cytokinesis IMP
IMP: 通过突变表型推断
22888021 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MRGPRX2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (47 - 279)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
蛋白主名 其他名称

mas-related G-protein coupled receptor member X2

G protein-coupled receptor MRGX2

关联疾病

疾病名称 别名
Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria
Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy
Mastocytosis, Cutaneous

Urticaria Pigmentosa

Cutaneous Mastocytosis

Diffuse Cutaneous Mastocytosis

Maculopapular Cutaneous Mastocytosis

Mastocytosis, Diffuse Cutaneous

MASTC

Mastocytosis, Maculopapular Cutaneous

Mastocytosis, Systemic, Somatic

Mastocytoma

Dcm

Diffuse Cutaneous Maculopapulous Mastocytosis

Up/Mpcm

Cm

Mastocytosis, Systemic

MASTSYS

Mast Cell Disease

Mast-Cell Disease

Mast Cell Leukemia

Mastocytosis, Indolent

Mastocytosis With Associated Hematologic Disorder

Mast Cell Neoplasm

Benign Mastocytoma
Rocuronium Allergy

Esmeron Allergy

Zemuron Allergy
Acute Anterolateral Myocardial Infarction

Acute Myocardial Infarction Of Anterolateral Wall
Mastocytosis

Mast Cell Disease

Mast Cell Hyperplasia

Urticaria Pigmentosa

Malignant Mastocytoma

Malignant Mast Cell Tumours

Malignant Mastocytosis
Chronic Inducible Urticaria
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Chlorhexidine Allergy
Vibratory Urticaria

Vibratory Angioedema

Dermodistortive Urticaria

VBU

Ddu

Angioedema, Vibratory
Physical Urticaria

Symptomatic Dermographism
Beta-Lactam Allergy
Dermatographia

Dermatographic Urticaria

Dermographism

Symptomatic Dermographism

Urticaria Factitia

Factitious Urticaria

Dermatographism
Cholinergic Urticaria
Corticosteroid Allergy
Drug Allergy

Allergy Drug

Drug Allergies
Cephalosporin Allergy
Chronic Urticaria

Urticaria Chronic

Chronic Spontaneous Urticaria

Chronic Ordinary Urticaria
Penicillin Allergy

Allergy To Penicillin
Indolent Systemic Mastocytosis

Ism
Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (21)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145191 MrgprX2 antagonist-1 99.80% 否
HY-P3419 PAMP-12 (unmodified) 99.30% 否
HY-146220 MrgprX2 antagonist-8 Antagonist 97.00% 否
HY-118069 (R)-ZINC-3573 Agonist 99.83% 否
HY-145192 MrgprX2 antagonist-2 99.20% 否
HY-145193 MrgprX2 antagonist-3 99.73% 否
HY-145195 MrgprX2 antagonist-5 ≥98.0% 否
HY-156907 ZINC49534341 Antagonist 99.13% 否
HY-B1158 Imidazolidinyl urea 99.90% 否
HY-145194 MrgprX2 antagonist-4 99.85% 否
HY-160540 MRGPRX2 modulator-1 Modulator 99.03% 否
HY-115682 (S)-ZINC-3573 99.89% 否
HY-145892 MrgprX2 antagonist-6 Antagonist / 否
HY-145893 MrgprX2 antagonist-7 Antagonist / 否
HY-158990 GE1111 Antagonist / 否
HY-173003 EP-3945 Agonist / 否
HY-P3419A PAMP-12 (unmodified) (TFA) Agonist / 否
HY-RS08651 MRGPRX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-145193A (R)-MrgprX2 antagonist-3 Antagonist / 否
HY-RS16850 Mrgprx2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23291 Mrgprx2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MRGPRX2 RGD RGD:738048
Others MRGPRX2 NCBI
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