2. Gene
  3. Cflar - CASP8 and FADD-like apoptosis regulator Gene

Cflar - CASP8 and FADD-like apoptosis regulator Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Flip

基因 ID: 117279 | 基因类型: protein coding

关于 Cflar

功能概要

Enables death receptor binding activity and protease binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in membrane raft. Part of CD95 death-inducing signaling complex. Orthologous to human CFLAR (CASP8 and FADD like Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Cflar 基因产物(2)

mRNA Protein Name
NM_001033864.4 NP_001029036.1 CASP8 and FADD-like apoptosis regulator isoform 1
NM_057138.3 NP_476479.1 CASP8 and FADD-like apoptosis regulator isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables death receptor binding IPI
IPI: 通过物理相互作用推断
17518537 RGD
enables protease binding IPI
IPI: 通过物理相互作用推断
17518537 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
17518537 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
16167066 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: 通过表达模式推断
16033771 RGD
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
26566102 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
12031707 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
18292530 RGD
involved in cellular response to nitric oxide IMP
IMP: 通过突变表型推断
18292530 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
12135878 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
14596792 RGD
involved in negative regulation of cellular response to transforming growth factor beta stimulus IMP
IMP: 通过突变表型推断
18314484 RGD
involved in negative regulation of epithelial cell apoptotic process IDA
IDA: 通过直接分析推断
18314484 RGD
involved in negative regulation of hepatocyte apoptotic process IMP
IMP: 通过突变表型推断
16167066 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IMP
IMP: 通过突变表型推断
18292530 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
23412386 RGD
involved in positive regulation of extracellular matrix organization IMP
IMP: 通过突变表型推断
24691542 RGD
involved in positive regulation of glomerular mesangial cell proliferation IMP
IMP: 通过突变表型推断
24691542 RGD
involved in positive regulation of hepatocyte proliferation IMP
IMP: 通过突变表型推断
16033771 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
20427667 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
23926673 RGD
involved in response to testosterone IDA
IDA: 通过直接分析推断
12811833 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CD95 death-inducing signaling complex IDA
IDA: 通过直接分析推断
16493077 RGD
part of death-inducing signaling complex IDA
IDA: 通过直接分析推断
17518537 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

CASP8 and FADD-like apoptosis regulator

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02570 CFLAR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21525 Cflar Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28043 Cflar Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cflar NCBI NCBI:8837
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