2. Gene
  3. Aqp4 - aquaporin 4 Gene

Aqp4 - aquaporin 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: WCH4

基因 ID: 11829 | 基因类型: protein coding

关于 Aqp4

功能概要

This gene encodes a member of the Aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant Aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]

Aqp4 基因产物(9)

mRNA Protein Name
NM_001308641.1 NP_001295570.1 aquaporin-4 isoform M23
NM_001308642.1 NP_001295571.1 aquaporin-4 isoform M23
NM_001308643.1 NP_001295572.1 aquaporin-4 isoform M23
NM_001308644.1 NP_001295573.1 aquaporin-4 isoform M23
NM_001308645.1 NP_001295574.1 aquaporin-4 isoform M23
NM_001308646.1 NP_001295575.1 aquaporin-4 isoform M23
NM_001308647.2 NP_001295576.1 aquaporin-4 isoform M23
NM_001317729.1 NP_001304658.1 aquaporin-4 isoform M1x
NM_009700.3 NP_033830.2 aquaporin-4 isoform M1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21262839 MGI
enables water channel activity IDA
IDA: 通过直接分析推断
8660998 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cerebrospinal fluid circulation IMP
IMP: 通过突变表型推断
22896675 MGI
involved in cerebrospinal fluid secretion IMP
IMP: 通过突变表型推断
30293570 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
10613915 MGI
involved in intracellular water homeostasis IDA
IDA: 通过直接分析推断
18286643 MGI
involved in multicellular organismal-level water homeostasis IDA
IDA: 通过直接分析推断
27751903 MGI
acts upstream of or within multicellular organismal-level water homeostasis IMP
IMP: 通过突变表型推断
12034763 MGI
acts upstream of or within renal water absorption IGI
IGI: 通过遗传相互作用推断
10662735 MGI
acts upstream of or within renal water absorption IMP
IMP: 通过突变表型推断
10662735 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
11406631 MGI
involved in water transport IDA
IDA: 通过直接分析推断
18286643 MGI
acts upstream of or within water transport IMP
IMP: 通过突变表型推断
10613915 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte end-foot IDA
IDA: 通过直接分析推断
22896675 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
10021464 MGI
located in cell-cell junction IDA
IDA: 通过直接分析推断
12673830 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
18718702 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16582023 MGI
located in sarcolemma IDA
IDA: 通过直接分析推断
29055082 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aquaporin-4

mercurial-insensitive water channel

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-115460 AER-271 96.90% Phase 1
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W008574 TGN-020 99.97% 否
HY-W008574A TGN-020 sodium 99.96% 否
HY-W176557 TGN-073 99.53% 否
HY-P10936A AQP4 (201-220) TFA 98.01% 否
HY-N10756 Hyp9 Agonist 99.90% 否
HY-RS00876 AQP4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-157226 ORI-TRN-002 Inhibitor / 否
HY-P10936 AQP4 (201-220) / 否
HY-P10937 AQP4 (205-215) / 否
HY-P10937A AQP4 (205-215) TFA / 否
HY-RS16702 Aqp4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23136 Aqp4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aqp4 NCBI NCBI:361
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