2. Gene
  3. Atp6v1a - ATPase, H+ transporting, lysosomal V1 subunit A Gene

Atp6v1a - ATPase, H+ transporting, lysosomal V1 subunit A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: VA68; VPP2; Atp6a1; Atp6a2; Atp6v1a1

基因 ID: 11964 | 基因类型: protein coding

关于 Atp6v1a

功能概要

Enables proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular iron ion homeostasis; cellular response to increased oxygen levels; and proton transmembrane transport. Predicted to act upstream of or within ion transport. Located in apical plasma membrane; cytosol; and microvillus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Orthologous to human ATP6V1A (ATPase H+ transporting V1 subunit A). [provided by Alliance of Genome Resources, Apr 2022]

Atp6v1a 基因产物(6)

mRNA Protein Name
NM_001358203.1 NP_001345132.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001358204.1 NP_001345133.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001413475.1 NP_001400404.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001413476.1 NP_001400405.1 V-type proton ATPase catalytic subunit A isoform 1
NM_001413477.1 NP_001400406.1 V-type proton ATPase catalytic subunit A isoform 2
NM_007508.6 NP_031534.2 V-type proton ATPase catalytic subunit A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables proton-transporting ATPase activity, rotational mechanism IMP
IMP: 通过突变表型推断
23863464 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in synaptic vesicle lumen acidification EXP
EXP: 通过实验结果推断
28793259 MGI
involved in synaptic vesicle lumen acidification IDA
IDA: 通过直接分析推断
28793259 MGI
involved in synaptic vesicle lumen acidification IMP
IMP: 通过突变表型推断
28793259 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ATPase complex IDA
IDA: 通过直接分析推断
28793259 MGI
located in apical plasma membrane IDA
IDA: 通过直接分析推断
18667600 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
23863464 MGI
located in cytosol IDA
IDA: 通过直接分析推断
16177003 MGI
located in microvillus IDA
IDA: 通过直接分析推断
18667600 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
16177003 MGI
part of proton-transporting V-type ATPase complex IDA
IDA: 通过直接分析推断
12527205 MGI
part of proton-transporting V-type ATPase, V1 domain IDA
IDA: 通过直接分析推断
28793259 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

V-type proton ATPase catalytic subunit A

70-kDa subunit

ATPase, H+ transporting, V1 subunit A

ATPase, H+ transporting, V1 subunit A1

ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha 70 kDa

ATPase, H+ transporting, lysosomal 70kD, V1 subunit A

V-ATPase 69 kDa subunit

V-ATPas

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-128892 EN6 Activator 99.42% 否
HY-RS29446 ATP6V1A Monkey Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01223 ATP6V1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18574 Atp6v1a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25058 Atp6v1a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atp6v1a NCBI NCBI:523
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