2. Gene
  3. CLTB - clathrin light chain B Gene

CLTB - clathrin light chain B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：网格蛋白轻链 B

种属: Homo sapiens

同用名: LCB

基因 ID: 1212 | 基因类型: protein coding

关于 CLTB

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,392,455-176,416,569 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 44.6), skin (RPKM 37.3) and 25 other tissues.

功能概要

网格蛋白是由重链和轻链组成的大型可溶性蛋白质。它作为涂层凹坑和囊泡的格子型细胞质面的主要结构成分，在受体介导的内吞作用过程中捕获特定的大分子。该基因编码两种网格蛋白轻链蛋白中的一种，据信其起调节元件的作用。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 7 月]

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

CLTB 基因产物(4)

mRNA Protein Name
NM_001364126.3 NP_001351055.1 clathrin light chain B isoform c
NM_001364127.2 NP_001351056.1 clathrin light chain B isoform d
NM_001834.5 NP_001825.1 clathrin light chain B isoform a
NM_007097.5 NP_009028.1 clathrin light chain B isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11889126 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLTB 蛋白结构

Clathrin_lg_ch

Clathrin_lg_ch: Clathrin light chain (1 - 227)

  • 0
  • 100
  • 200
  • 229 a.a.
蛋白主名 其他名称

clathrin light chain B

clathrin, light chain (Lcb)

关联疾病

疾病名称 别名
Leber Congenital Amaurosis 1

LCA1

Amaurosis Congenita Of Leber I

Lca

Retinal Blindness, Congenital

Crb

Leber Congenital Amaurosis Type I

Leber Congenital Amaurosis, Type 1

Amaurosis Congenita Of Leber, Type 1
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-106929 Moxilubant Antagonist 99.83% 否
HY-RS02844 CLTB Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CLTB MGD MGI:1921575
Rattus norvegicus CLTB RGD RGD:621353
Macaca mulatta CLTB VGNC VGNC:71267
Felis catus CLTB VGNC VGNC:60983
Bos taurus CLTB VGNC VGNC:27470
Canis familiaris CLTB VGNC VGNC:39366
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