Brca1 - breast cancer 1, early onset Gene

种属: Mus musculus

关于 Brca1

功能概要

Enables damaged DNA binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including regulation of gene expression by genetic imprinting; regulation of histone modification; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within several processes, including centrosome cycle; dosage compensation by inactivation of X chromosome; and mitotic G2/M transition checkpoint. Located in condensed nuclear chromosome and cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study breast Cancer. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); cervix uteri carcinoma in situ; gastrointestinal system Cancer (multiple); hereditary breast ovarian Cancer syndrome; and reproductive organ Cancer (multiple). Orthologous to human BRCA1 (BRCA1 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]