2. Gene
  3. Cacna1d - calcium channel, voltage-dependent, L type, alpha 1D subunit Gene

Cacna1d - calcium channel, voltage-dependent, L type, alpha 1D subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cach3; Cacn4; Cav1.3; Cchl1a; D-LTCC; Cchl1a2; Cacnl1a2; 8430418G19Rik

基因 ID: 12289 | 基因类型: protein coding

关于 Cacna1d

功能概要

This gene encodes a pore-forming subunit of the L-type, voltage-activated Calcium Channel family. These channels have been found to play a role in heart and smooth muscle contraction and in the transmission of auditory information. Homozygous knockout mice for this gene exhibit deafness and heart defects. These channels have also been linked to mitochondrial oxidative stress in a mouse model of Parkinson's disease. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]

Cacna1d 基因产物(3)

mRNA Protein Name
NM_001083616.2 NP_001077085.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform 2
NM_001302637.1 NP_001289566.1 voltage-dependent L-type calcium channel subunit alpha-1D isoform 3
NM_028981.3 NP_083257.2 voltage-dependent L-type calcium channel subunit alpha-1D isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ankyrin binding IPI
IPI: 通过物理相互作用推断
21859974 MGI
enables high voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
12900400 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10468580 MGI
enables voltage-gated calcium channel activity involved SA node cell action potential IMP
IMP: 通过突变表型推断
15932895 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
IDA: 通过直接分析推断
10929716 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IMP
IMP: 通过突变表型推断
10929716 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
16706838 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
12700358 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
12700358 MGI
acts upstream of or within membrane depolarization during SA node cell action potential IMP
IMP: 通过突变表型推断
12700358 MGI
involved in positive regulation of adenylate cyclase activity IDA
IDA: 通过直接分析推断
24086669 MGI
involved in regulation of atrial cardiac muscle cell membrane repolarization IMP
IMP: 通过突变表型推断
17110593 MGI
acts upstream of or within regulation of heart rate by cardiac conduction IMP
IMP: 通过突变表型推断
12700358 MGI
involved in regulation of potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
17110593 MGI
involved in regulation of potassium ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
17110593 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
17074442 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Z disc IDA
IDA: 通过直接分析推断
17110593 MGI
is active in cochlear hair cell ribbon synapse IDA
IDA: 通过直接分析推断
10929716 MGI
is active in cochlear hair cell ribbon synapse IMP
IMP: 通过突变表型推断
10929716 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
10468580 MGI
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
16354915 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

voltage-dependent L-type calcium channel subunit alpha-1D

Cav1.3alpha1

alpha 1 E

calcium channel, L type, alpha-1 polypeptide

voltage-gated calcium channel subunit alpha Cav1.3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01794 CACNA1D Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20625 Cacna1d Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27134 Cacna1d Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cacna1d NCBI NCBI:776
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