Calcr - calcitonin receptor Gene

中文名称：降钙素受体

种属: Mus musculus

同用名: Clr; Ct-r

关于 Calcr

功能概要

该基因编码的蛋白可启动降钙素受体活性。作用于多个过程的上游或内部，包括腺苷酸环化酶激活 G 蛋白偶联受体信号通路；骨化的负调节；和破骨细胞分化。位于顶体小泡和纤毛中。以多种结构表达，包括大脑；性腺;四肢长骨；乳腺原基；和感觉器官。该基因的人类直系同源物与骨质疏松症有关。与人类 CALCR（降钙素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Calcitonin receptor activity. Acts upstream of or within several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of ossification; and osteoclast differentiation. Located in acrosomal vesicle and cilium. Is expressed in several structures, including brain; gonad; limb long bone; mammary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (Calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]