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  2. Casp4 - caspase 4, apoptosis-related cysteine peptidase Gene

Casp4 - caspase 4, apoptosis-related cysteine peptidase Gene

中文名称:半胱天冬酶 4,细胞凋亡相关的半胱氨酸肽酶

种属: Mus musculus

同用名: Caspl; ich-3; CASP-4; Casp11; CASP-11

基因 ID: 12363 | 基因类型: protein coding

关于 Casp4

Chromosome 9: 5,308,828-5,336,783 forward strand.GRCm39:CM001002.3

This gene has 7 transcripts (splice variants), 252 orthologues, 11 paralogues and is associated with 21 phenotypes. Biased expression in large intestine adult (RPKM 7.7), bladder adult (RPKM 4.) and 14 other tissues.


该基因编码在细胞凋亡、细胞迁移和炎症反应中起重要作用的半胱氨酸蛋白酶成员。编码的蛋白质介导巨噬细胞在细菌感染后产生促炎细胞因子。缺乏编码蛋白的小鼠对脂多糖诱导的内毒素休克有抵抗力。已经描述了包含剪接受体连接的 5-bp 缺失,导致某些小鼠品系中的交替剪接和较短的非功能性亚型。尽管其官方命名为“caspase 4,细胞凋亡相关的半胱氨酸肽酶”,但该基因及其编码的蛋白质在历史上被称为 Caspase 11。该基因存在于 9 号染色体上的三个 Caspase 基因簇中。[RefSeq 提供,4 月2015]

This gene encodes a member of the cysteine proteases that plays important roles in Apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon Bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called Caspase 11. This gene is present in a cluster of three Caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]

Casp4 基因产物(7)

mRNA Protein Name
NM_001379320.1 NP_001366249.1 caspase-4 isoform 4
NM_001379318.1 NP_001366247.1 caspase-4 isoform 2
NM_001379319.1 NP_001366248.1 caspase-4 isoform 3
NM_001379321.1 NP_001366250.1 caspase-4 isoform 5
NM_001379323.1 NP_001366252.1 caspase-4 isoform 7
NM_007609.3 NP_031635.2 caspase-4 isoform 1
NM_001379322.1 NP_001366251.1 caspase-4 isoform 6

Casp4 蛋白结构


CARD_CASP1-like: cd08325 (4 - 84)


CASc: smart00115 (121 - 370)

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  • 373 a.a.
蛋白主名 其他名称


caspase 11, apoptosis-related cysteine peptidase

caspase 11, apoptosis-related cysteine protease

caspase 4, apoptosis-related cysteine protease

caspase-11 short form splicing

protease ICH-3


种属 基因名 来源 基因 ID
Homo sapiens Casp4 NCBI NCBI:837