Casp4 - caspase 4, apoptosis-related cysteine peptidase Gene

中文名称：半胱天冬酶 4,细胞凋亡相关的半胱氨酸肽酶

种属: Mus musculus

同用名: Caspl; ich-3; CASP-4; Casp11; CASP-11

关于 Casp4

功能概要

该基因编码在细胞凋亡、细胞迁移和炎症反应中起重要作用的半胱氨酸蛋白酶成员。编码的蛋白质介导巨噬细胞在细菌感染后产生促炎细胞因子。缺乏编码蛋白的小鼠对脂多糖诱导的内毒素休克有抵抗力。已经描述了包含剪接受体连接的 5-bp 缺失，导致某些小鼠品系中的交替剪接和较短的非功能性亚型。尽管其官方命名为“caspase 4，细胞凋亡相关的半胱氨酸肽酶”，但该基因及其编码的蛋白质在历史上被称为 Caspase 11。该基因存在于 9 号染色体上的三个 Caspase 基因簇中。[RefSeq 提供，4 月2015]

This gene encodes a member of the cysteine proteases that plays important roles in Apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon Bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called Caspase 11. This gene is present in a cluster of three Caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]