2. Gene
  3. Cbfb - core binding factor beta Gene

Cbfb - core binding factor beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PEA2; Pebp2; PEBP2b; Pebpb2

基因 ID: 12400 | 基因类型: protein coding

关于 Cbfb

功能概要

Contributes to sequence-specific DNA binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of CD8-positive, alpha-beta T cell differentiation. Acts upstream of or within several processes, including hemopoiesis; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CBFB (core-binding factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Cbfb 基因产物(4)

mRNA Protein Name
NM_001161456.1 NP_001154928.1 core-binding factor subunit beta isoform 2
NM_001161457.1 NP_001154929.1 core-binding factor subunit beta isoform 3
NM_001161458.1 NP_001154930.1 core-binding factor subunit beta isoform 4
NM_022309.4 NP_071704.3 core-binding factor subunit beta isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11404095 MGI
contributes to sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18258917 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell maturation IMP
IMP: 通过突变表型推断
12434156 MGI
acts upstream of or within definitive hemopoiesis IMP
IMP: 通过突变表型推断
9159135 MGI
acts upstream of or within lymphocyte differentiation IMP
IMP: 通过突变表型推断
12434155 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: 通过突变表型推断
12434155 MGI
involved in negative regulation of CD4-positive, alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
18258917 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18258917 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
12434155 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
12434156 MGI
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
18258917 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12434156 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12434156 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

core-binding factor subunit beta

CBF-beta

PEA2-beta

PEBP2-beta

SL3-3 enhancer factor 1 subunit beta

SL3/AKV core-binding factor beta subunit

polyomavirus enhancer-binding protein 2 beta subunit

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108470 Ro5-3335 Inhibitor 99.52% 否
HY-RS01995 CBFB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-124137 Runx1-CBFβ interaction inhibitor 1 Inhibitor / 否
HY-RS09271 NFYA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09272 NFYB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174541 Human RUNX1 mRNA / 否
HY-RS18748 Cbfb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20307 Nfya Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25235 Cbfb Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26815 Nfya Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cbfb NCBI NCBI:865
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