2. Gene
  3. Cbl - Casitas B-lineage lymphoma Gene

Cbl - Casitas B-lineage lymphoma Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: cbl; Cbl-2; c-Cbl; 4732447J05Rik

基因 ID: 12402 | 基因类型: protein coding

关于 Cbl

功能概要

Enables SH3 domain binding activity and Ephrin Receptor binding activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within regulation of Rap protein signal transduction. Located in Golgi apparatus and cilium. Part of flotillin complex. Is expressed in male reproductive system and urinary system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; lung non-small cell carcinoma; and myeloid neoplasm. Orthologous to human CBL (Cbl proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Cbl 基因产物(1)

mRNA Protein Name
NM_007619.2 NP_031645.2 E3 ubiquitin-protein ligase CBL
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
9447983 MGI
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
18034775 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7657591 MGI
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
15383614 MGI
enables ubiquitin protein ligase activity IGI
IGI: 通过遗传相互作用推断
11823423 MGI
enables ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
12754251 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of epidermal growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
23457600 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
11823423 MGI
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
12754251 MGI
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
23457600 MGI
acts upstream of or within regulation of Rap protein signal transduction IMP
IMP: 通过突变表型推断
12671687 MGI
involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
IMP: 通过突变表型推断
29237719 MGI
involved in ubiquitin-dependent endocytosis IMP
IMP: 通过突变表型推断
15383614 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
23457600 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
29237719 MGI
located in cilium IDA
IDA: 通过直接分析推断
29237719 MGI
part of flotillin complex IDA
IDA: 通过直接分析推断
11001060 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
15383614 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase CBL

RING-type E3 ubiquitin transferase CBL

casitas B-lineage lymphoma proto-oncogene

proto-oncogene c-CBL

signal transduction protein CBL

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-18935A CBL0137 hydrochloride 99.72% Phase 2
Pre-clinical Phase
生物活性分子 (35)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18935 CBL0137 99.68% 否
HY-141432 NX-1607 Inhibitor 99.87% 否
HY-136339 Cbl-b-IN-1 Inhibitor 99.66% 否
HY-W176629 Hydrocotarnine Inhibitor 99.70% 否
HY-155120 Cbl-b-IN-5 Inhibitor 99.61% 否
HY-141431 Cbl-b-IN-2 Inhibitor / 否
HY-E70079 Cystathionine β-lyase, Recombinant Microorganisms / 否
HY-156766 Cbl-b-IN-10 Inhibitor / 否
HY-156768 Cbl-b-IN-12 Inhibitor / 否
HY-P10412 A11 Inhibitor 98.49% 否
HY-155477 Cbl-b-IN-15 Inhibitor / 否
HY-156762 Cbl-b-IN-6 Inhibitor / 否
HY-156763 Cbl-b-IN-7 Inhibitor / 否
HY-156764 Cbl-b-IN-8 Inhibitor / 否
HY-156765 Cbl-b-IN-9 Inhibitor / 否
HY-156767 Cbl-b-IN-11 Inhibitor / 否
HY-156769 Cbl-b-IN-13 Inhibitor / 否
HY-158171 Cbl-b-IN-17 Inhibitor / 否
HY-158172 Cbl-b-IN-18 Inhibitor / 否
HY-158173 Cbl-b-IN-19 Inhibitor / 否
HY-158174 Cbl-b-IN-20 Inhibitor / 否
HY-159608 PROTAC Cbl-b-IN-1 / 否
HY-159615 Cbl-b-IN-21 / 否
HY-159617 Cbz-Pip-2C-Pip-C-Pip / 否
HY-159618 (3S)Lenalidomide-5-Pip-C-Pip-2C-Pip / 否
HY-161977 Cbl-b-IN-26 Inhibitor / 否
HY-163194 Cbl-b-IN-16 Inhibitor / 否
HY-169005 Cbl-b-IN-27 Inhibitor / 否
HY-173311 Cbl-b-IN-28 / 否
HY-P10412A A11 acetate Inhibitor 98.48% 否
HY-RS01996 CBL Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W797329 (3S)Lenalidomide-5-Br / 否
HY-141432G NX-1607 (GMP) Inhibitor / 否
HY-RS17014 Cbl Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23457 Cbl Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cbl NCBI NCBI:867
Rattus norvegicus Cbl NCBI NCBI:500985
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