1. Gene
  2. WFIKKN2 - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Gene

WFIKKN2 - WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 Gene

中文名称:含 WAP、follistatin/kazal、免疫球蛋白、kunitz 和 netrin 结构域 2

种属: Homo sapiens

同用名: GASP-1; WFDC20B; hGASP-1; WFIKKNRP

基因 ID: 124857 | 基因类型: protein coding

关于 WFIKKN2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,834,584-50,842,353 (from NCBI)

This gene has 2 transcripts (splice variants), 148 orthologues and 13 paralogues. Biased expression in ovary (RPKM 30.8) and testis (RPKM 1.8).

功能概要

WFIKKN1 蛋白包含一个 WAP 结构域、卵泡抑素结构域、免疫球蛋白结构域、两个串联 Kunitz 结构域和一个 NTR 结构域。该基因编码 WFIKKN1 相关蛋白,该蛋白具有与 WFIKKN1 蛋白相同的结构域结构。 WAP 型、follistatin 型、Kunitz 型和 NTR 型蛋白酶抑制结构域可能控制多种蛋白酶的作用。[RefSeq 提供,2008 年 7 月]

The WFIKKN1 protein contains a WAP domain, Follistatin domain, immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. This gene encodes a WFIKKN1-related protein which has the same domain organization as the WFIKKN1 protein. The WAP-type, Follistatin type, Kunitz-type, and NTR-type protease inhibitory domains may control the action of multiple types of proteases. [provided by RefSeq, Jul 2008]

WFIKKN2 基因产物(2)

mRNA Protein Name
NM_001330341.2 NP_001317270.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 2
NM_175575.6 NP_783165.1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 isoform 1 precursor

WFIKKN2 蛋白结构

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (42 - 90)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (138 - 168)

I-set

I-set: Immunoglobulin I-set domain (213 - 304)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (328 - 379)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (385 - 436)

NTR

NTR: UNC-6/NTR/C345C module (457 - 559)

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  • 576 a.a.
蛋白主名 其他名称

WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2

WAP four-disulfide core domain 20B

重组 WFIKKN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75173 GASP-1/WFIKKN2 Protein, Human (HEK293, His) Q8TEU8 (L35-H576) ≥95%

关联疾病

疾病名称 别名
Space Motion Sickness
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus WFIKKN2 MGD MGI:2669209
Bos taurus WFIKKN2 VGNC VGNC:55888
Canis familiaris WFIKKN2 VGNC VGNC:104174
Felis catus WFIKKN2 VGNC VGNC:99574
Macaca mulatta WFIKKN2 VGNC VGNC:79900
Rattus norvegicus WFIKKN2 RGD RGD:1305361
Others WFIKKN2 NCBI