2. Gene
  3. Cfl1 - cofilin 1, non-muscle Gene

Cfl1 - cofilin 1, non-muscle Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Cof

基因 ID: 12631 | 基因类型: protein coding

关于 Cfl1

功能概要

Enables actin filament binding activity and signaling receptor binding activity. Involved in Cytoskeleton organization; positive regulation of actin filament depolymerization; and positive regulation of embryonic development. Acts upstream of or within several processes, including neural crest cell migration; neural fold formation; and response to amino acid. Located in cell-cell junction; cortical actin cytoskeleton; and lamellipodium. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and immune system. Orthologous to human CFL1 (cofilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cfl1 基因产物(1)

mRNA Protein Name
NM_007687.5 NP_031713.1 cofilin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin filament binding IDA
IDA: 通过直接分析推断
11809832 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
25208553 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
24052308 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament depolymerization IDA
IDA: 通过直接分析推断
11809832 MGI
involved in actin filament fragmentation IDA
IDA: 通过直接分析推断
11809832 MGI
acts upstream of or within actin filament organization IMP
IMP: 通过突变表型推断
15649475 MGI
involved in actin filament organization IMP
IMP: 通过突变表型推断
25208553 MGI
acts upstream of or within cell motility IMP
IMP: 通过突变表型推断
15548599 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: 通过突变表型推断
15649475 MGI
involved in establishment of spindle localization IMP
IMP: 通过突变表型推断
25208553 MGI
acts upstream of or within mitotic cytokinesis IMP
IMP: 通过突变表型推断
15548599 MGI
acts upstream of or within neural crest cell migration IMP
IMP: 通过突变表型推断
15649475 MGI
acts upstream of or within neural fold formation IMP
IMP: 通过突变表型推断
15649475 MGI
involved in positive regulation of actin filament depolymerization IDA
IDA: 通过直接分析推断
23921380 MGI
acts upstream of or within positive regulation of actin filament depolymerization IMP
IMP: 通过突变表型推断
15548599 MGI
involved in positive regulation of embryonic development IMP
IMP: 通过突变表型推断
25208553 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
17018287 MGI
acts upstream of or within response to amino acid IDA
IDA: 通过直接分析推断
17018287 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
located in cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
15004221 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15548599 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16388910 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
25107909 MGI
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
16388910 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cofilin-1

n-cofilin

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15700 VPS72 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS02568 CFL1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18607 Cfl1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25093 Cfl1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cfl1 NCBI NCBI:1072
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