2. Gene
  3. Clcn2 - chloride channel, voltage-sensitive 2 Gene

Clcn2 - chloride channel, voltage-sensitive 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Clc2; ClC-2; nmf240

基因 ID: 12724 | 基因类型: protein coding

关于 Clcn2

功能概要

Enables voltage-gated Chloride Channel activity. Acts upstream of or within cell differentiation involved in salivary gland development and retina development in camera-type eye. Predicted to be located in dendrite; perikaryon; and plasma membrane. Predicted to be part of Chloride Channel complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; gonad; hindlimb phalanx; notochord; and visual system. Used to study leukodystrophy. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 11 and primary hyperaldosteronism. Orthologous to human CLCN2 (chloride voltage-gated channel 2). [provided by Alliance of Genome Resources, Apr 2022]

Clcn2 基因产物(1)

mRNA Protein Name
NM_009900.2 NP_034030.2 chloride channel protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22405205 MGI
enables voltage-gated chloride channel activity IMP
IMP: 通过突变表型推断
11976342 MGI
enables voltage-gated monoatomic anion channel activity IDA
IDA: 通过直接分析推断
26666914 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within acinar cell differentiation IMP
IMP: 通过突变表型推断
11976342 MGI
acts upstream of or within cell differentiation involved in salivary gland development IMP
IMP: 通过突变表型推断
11976342 MGI
involved in chloride transport IMP
IMP: 通过突变表型推断
20357128 MGI
involved in regulation of resting membrane potential IMP
IMP: 通过突变表型推断
20357128 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
21052544 MGI
involved in stabilization of membrane potential IMP
IMP: 通过突变表型推断
20357128 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte end-foot IDA
IDA: 通过直接分析推断
17567819 MGI
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
16155254 MGI
located in myelin sheath IDA
IDA: 通过直接分析推断
17567819 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

chloride channel protein 2

chloride channel 2

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0680 Lubiprostone (hemiketal) Activator / 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02754 CLCN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS22442 Clcn2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS28965 Clcn2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Clcn2 NCBI NCBI:1181
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