1. Gene
  2. PODN - podocan Gene

PODN - podocan Gene

中文名称:波多坎

种属: Homo sapiens

同用名: PCAN; SLRR5A

基因 ID: 127435 | 基因类型: protein coding

关于 PODN

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,062,213-53,085,494 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues and 22 paralogues. Broad expression in gall bladder (RPKM 52.1), ovary (RPKM 37.5) and 19 other tissues.

功能概要

由该基因编码的蛋白质是富含亮氨酸的小重复蛋白家族的成员,包含一个氨基末端 CX3CXCX7C 富含半胱氨酸簇,后跟一个富含亮氨酸的重复域。研究表明,这种蛋白质可以起到抑制动脉损伤后平滑肌细胞增殖和迁移的作用。[RefSeq 提供,2016 年 7 月]

The protein encoded by this gene is a member of the small leucine-rich repeat protein family and contains an amino terminal CX3CXCX7C cysteine-rich cluster followed by a leucine-rich repeat domain. Studies suggest that this protein could function to inhibit smooth muscle cell proliferation and migration following arterial injury. [provided by RefSeq, Jul 2016]

PODN 基因产物(3)

mRNA Protein Name
NM_001199080.4 NP_001186009.2 podocan precursor
NM_001199081.3 NP_001186010.2 podocan precursor
NM_153703.5 NP_714914.3 podocan precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IDA
IDA: 通过直接分析推断
15063725 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
15063725 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15063725 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15063725 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
15063725 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PODN 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (147 - 206)

LRR_8

LRR_8: Leucine rich repeat (286 - 348)

LRR_8

LRR_8: Leucine rich repeat (358 - 419)

LRR_8

LRR_8: Leucine rich repeat (429 - 490)

LRR_1

LRR_1: Leucine Rich Repeat (550 - 567)

LRR_8

LRR_8: Leucine rich repeat (571 - 630)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
蛋白主名 其他名称

podocan

podocan proteoglycan

关联疾病

疾病名称 别名
Joubert Syndrome 9

JBTS9

Joubert Syndrome, Type 9

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PODN VGNC VGNC:33101
Felis catus PODN VGNC VGNC:64273
Rattus norvegicus PODN RGD RGD:7545693
Canis familiaris PODN VGNC VGNC:44763
Macaca mulatta PODN VGNC VGNC:76096
Mus musculus PODN MGD MGI:2674939