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  2. Ccr7 - chemokine (C-C motif) receptor 7 Gene

Ccr7 - chemokine (C-C motif) receptor 7 Gene

中文名称:趋化因子 (CC 基序) 受体 7

种属: Mus musculus

同用名: EBI1; CCR-7; CD197; Ebi1h; Cdw197; Cmkbr7; CC-CKR-7

基因 ID: 12775 | 基因类型: protein coding

关于 Ccr7

Chromosome 11: 99,035,022-99,045,903 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 197 orthologues, 25 paralogues and is associated with 48 phenotypes. Biased expression in spleen adult (RPKM 74.8), thymus adult (RPKM 7.1) and 2 other tissues.

功能概要

该基因编码的蛋白可启动 CC 趋化因子受体活性。参与多个过程,包括免疫反应的正调节;白细胞趋化性的正调节;和调节细胞因子的产生。在趋化性上游或趋化性内起作用;细胞数量的稳态;和免疫反应。位于质膜外侧。以多种结构表达,包括消化系统;中枢神经系统;免疫系统;生殖系统;和白色脂肪。用于研究干燥综合征。与人 CCR7(CC 基序趋化因子受体 7)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables C-C Chemokine Receptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of leukocyte chemotaxis; and regulation of cytokine production. Acts upstream of or within chemotaxis; homeostasis of number of cells; and immune response. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; immune system; reproductive system; and white fat. Used to study Sjogren's syndrome. Orthologous to human CCR7 (C-C motif Chemokine Receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Ccr7 基因产物(2)

mRNA Protein Name
NM_001301713.1 NP_001288642.1 C-C chemokine receptor type 7 isoform b
NM_007719.2 NP_031745.2 C-C chemokine receptor type 7 isoform a precursor

Ccr7 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (58 - 336)

7tm_GPCRs

7tm_GPCRs: cd14964 (60 - 84)

7tm_GPCRs

7tm_GPCRs: cd14964 (93 - 114)

7tm_GPCRs

7tm_GPCRs: cd14964 (129 - 151)

7tm_GPCRs

7tm_GPCRs: cd14964 (176 - 192)

7tm_GPCRs

7tm_GPCRs: cd14964 (220 - 243)

7tm_GPCRs

7tm_GPCRs: cd14964 (261 - 283)

7tm_GPCRs

7tm_GPCRs: cd14964 (304 - 329)

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  • 378 a.a.
蛋白主名 其他名称

C-C chemokine receptor type 7

EBV-induced G-protein coupled receptor 1

MIP-3 beta receptor

chemokine (C-C) receptor 7

epstein-Barr virus-induced G-protein coupled receptor 1

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccr7 NCBI NCBI:1236