2. Gene
  3. Col4a2 - collagen, type IV, alpha 2 Gene

Col4a2 - collagen, type IV, alpha 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Col4a-2

基因 ID: 12827 | 基因类型: protein coding

关于 Col4a2

功能概要

This gene encodes the alpha-2 subunit of the type IV collagens, an essential component of basement membranes. The encoded protein forms a triple helical heterotrimer comprised of alpha-1 and alpha-2 subunits that assembles into a type IV Collagen network. Canstatin, a peptide derived fom the C-terminus of the Collagen chain, is a matrikine that has been shown to inhibit angiogenesis. Homozygous knockout mice for this gene exhibit impaired basement membrane integrity and embryonic lethality. This gene shares a bi-directional promoter with a related gene on chromosome 8. [provided by RefSeq, Nov 2015]

Col4a2 基因产物(1)

mRNA Protein Name
NM_009932.4 NP_034062.3 collagen alpha-2(IV) chain precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated transcription IDA
IDA: 通过直接分析推断
17525254 MGI
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
17525254 MGI
acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
10970885 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
11732842 MGI
part of collagen type IV trimer IDA
IDA: 通过直接分析推断
12101409 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

collagen alpha-2(IV) chain

canstatin

procollagen, type IV, alpha 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02984 COL4A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18703 Col4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25190 Col4a2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Col4a2 NCBI NCBI:1284
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