2. Gene
  3. Crem - cAMP responsive element modulator Gene

Crem - cAMP responsive element modulator Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ICER; ICERI

基因 ID: 12916 | 基因类型: protein coding

关于 Crem

功能概要

This gene encodes a basic-leucine zipper domain-containing protein that localizes to gene promoters, where it binds to the cyclic AMP response element (CRE). Different protein isoforms encoded by this gene may function as either activators or repressors of transcription. Activity of this gene is important in multiple developmental processes, including spermatogenesis. Mutation of this gene causes male infertility. Alternative splicing and promoter usage result in multiple transcript variants for this gene. [provided by RefSeq, Oct 2012]

Crem 基因产物(18)

mRNA Protein Name
NM_001110850.2 NP_001104320.1 cAMP-responsive element modulator isoform 4
NM_001110851.1 NP_001104321.1 cAMP-responsive element modulator isoform 7
NM_001110852.1 NP_001104322.1 cAMP-responsive element modulator isoform 8
NM_001110853.2 NP_001104323.1 cAMP-responsive element modulator isoform 9
NM_001110854.1 NP_001104324.2 cAMP-responsive element modulator isoform 10
NM_001110855.1 NP_001104325.2 cAMP-responsive element modulator isoform 11
NM_001110856.2 NP_001104326.1 cAMP-responsive element modulator isoform 2
NM_001110857.2 NP_001104327.1 cAMP-responsive element modulator isoform 5
NM_001110858.2 NP_001104328.1 cAMP-responsive element modulator isoform 6
NM_001110859.2 NP_001104329.1 cAMP-responsive element modulator isoform 1
NM_001271503.1 NP_001258432.1 cAMP-responsive element modulator isoform 12
NM_001271504.1 NP_001258433.1 cAMP-responsive element modulator isoform 13
NM_001271505.1 NP_001258434.1 cAMP-responsive element modulator isoform 14
NM_001271506.1 NP_001258435.1 cAMP-responsive element modulator isoform 15
NM_001311066.1 NP_001297995.1 cAMP-responsive element modulator isoform 16
NM_001311067.1 NP_001297996.1 cAMP-responsive element modulator isoform 17
NM_001374833.1 NP_001361762.1 cAMP-responsive element modulator isoform 18
NM_013498.3 NP_038526.2 cAMP-responsive element modulator isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11354513 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23443664 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17056544 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian regulation of gene expression IMP
IMP: 通过突变表型推断
23443664 MGI
involved in circadian rhythm IEP
IEP: 通过表达模式推断
23443664 MGI
acts upstream of or within glycosphingolipid metabolic process IMP
IMP: 通过突变表型推断
18308723 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
23443664 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
20488182 MGI
involved in response to cAMP IDA
IDA: 通过直接分析推断
23443664 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
14757819 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23443664 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
11354513 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cAMP-responsive element modulator

cAMP responsive element moderator

inducible cAMP early repressor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03165 CREM Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20710 Crem Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27221 Crem Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Crem NCBI NCBI:1390
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