TAF8 - TATA-box binding protein associated factor 8 Gene

中文名称：TATA-box 结合蛋白相关因子 8

种属: Homo sapiens

同用名: II; TAF; TBN; NEDMLHB; TAFII43; TAFII-43; TAF(II)43

关于 TAF8

功能概要

该基因编码几种 TATA 结合蛋白 (TBP) 相关因子 (TAF) 之一，这些因子是一般转录因子复合体 TFIID 的完整亚基。 TFIID 识别许多基因的核心启动子，并使包含 RNA 聚合酶 II 和其他起始因子的转录预起始复合物的组装成核。该基因编码的蛋白质包含一个 H4 样组蛋白折叠结构域，并与 TFIID 的几个亚基相互作用，包括 TBP 和组蛋白折叠蛋白 TAF10。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2008 年 7 月]

This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and Other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]