1. Gene
  2. ADH6 - alcohol dehydrogenase 6 (class V) Gene

ADH6 - alcohol dehydrogenase 6 (class V) Gene

中文名称:醇脱氢酶 6 (V 类)

种属: Homo sapiens

同用名: ADH-5

基因 ID: 130 | 基因类型: protein coding

关于 ADH6

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,202,639-99,219,246 (from NCBI)

This gene has 8 transcripts (splice variants), 375 orthologues and 17 paralogues. Biased expression in liver (RPKM 139.0), duodenum (RPKM 20.7) and 2 other tissues.

功能概要

该基因编码 V 类乙醇脱氢酶,它是乙醇脱氢酶家族的成员。该家族的成员代谢多种底物,包括乙醇、视黄醇、其他脂肪醇、羟基类固醇和脂质过氧化产物。该基因在胃和肝脏中都有表达,它在其 5' UTR 上游包含一个糖皮质激素反应元件,这是一个类固醇激素受体结合位点。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ADH6 基因产物(2)

mRNA Protein Name
NM_000672.4 NP_000663.1 alcohol dehydrogenase 6 isoform 2
NM_001102470.2 NP_001095940.1 alcohol dehydrogenase 6 isoform 1

ADH6 蛋白结构

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (35 - 160)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (203 - 331)

  • 0
  • 100
  • 200
  • 300
  • 368 a.a.
蛋白主名 其他名称

alcohol dehydrogenase 6

aldehyde reductase

关联疾病

疾病名称 别名
Proliferative Type Fibrocystic Change Of Breast

Fibrocystic Change, Proliferative Type With Atypia

Fibrocystic Disease, Proliferative Type With Atypia

Proliferating Lesion Of Breast Without Atypia

Proliferating Lesion Of The Breast Without Atypia

Proliferative Fibrocystic Change

Breast Fibrocystic Change, Proliferative Type

Amed Syndrome, Digenic

Amed Syndrome

AMEDS

Bone Marrow Failure Syndrome 7, Digenic

Bmfs7

Aplastic Anemia-Intellectual Disability-Dwarfism Syndrome

Breast Intraductal Proliferative Lesion

Intraductal Proliferative Lesion

Intraductal Proliferative Lesion Of The Breast

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Alcohol Dependence, Protection Against

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Alzheimer Disease 3

AD3

Alzheimer Disease, Type 3

Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia

Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques

Alzheimer'S Disease 3

Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia

Alzheimer Disease 3, Early-Onset

Alzheimer Disease, Familial, 3

Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch

Alzheimer Disease 3, Early Onset

Alzheimer Disease Familial 3

Early-Onset Familial Alzheimer Disease 3

Familial Alzheimer Disease 3

Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia

Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques

Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques

Alzheimer Disease, Familial, Type 3

Focal Dermal Hypoplasia

Goltz Syndrome

Goltz-Gorlin Syndrome

FDH

FODH

Dhof

Goltz Gorlin Syndrome

Hypoplasia, Dermal, Focal

Substance Dependence
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ADH6 RGD RGD:1306313
Mus musculus ADH6 MGD MGI:2446626