2. Gene
  3. Cyp46a1 - cytochrome P450, family 46, subfamily a, polypeptide 1 Gene

Cyp46a1 - cytochrome P450, family 46, subfamily a, polypeptide 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CH24H; Cyp46

基因 ID: 13116 | 基因类型: protein coding

关于 Cyp46a1

功能概要

Enables Cholesterol 24-hydroxylase activity. Involved in Cholesterol catabolic process and regulation of long-term synaptic potentiation. Acts upstream of with a negative effect on protein localization to membrane raft. Located in several cellular components, including dendrite; endoplasmic reticulum membrane; and postsynapse. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina nuclear layer; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (Cytochrome P450 family 46 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp46a1 基因产物(1)

mRNA Protein Name
NM_010010.3 NP_034140.1 cholesterol 24-hydroxylase precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cholesterol 24-hydroxylase activity IDA
IDA: 通过直接分析推断
10377398 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cholesterol catabolic process IDA
IDA: 通过直接分析推断
10377398 MGI
acts upstream of negative effect protein localization to membrane raft IDA
IDA: 通过直接分析推断
20193040 MGI
involved in regulation of long-term synaptic potentiation IMP
IMP: 通过突变表型推断
16505352 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
18241055 MGI
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
18241055 MGI
located in postsynapse IDA
IDA: 通过直接分析推断
16505352 MGI
located in presynapse IDA
IDA: 通过直接分析推断
16505352 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cholesterol 24-hydroxylase

cholesterol 24-monooxygenase

cholesterol 24S-hydroxylase

cholestrol 24-hydroxylase

cytochrome P450, 46a1 (cholesterol 24-hydroxylase)

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-109123 Soticlestat Inhibitor 99.83% Phase 3
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-144309 Cholesterol 24-hydroxylase-IN-1 Inhibitor 99.53% 否
HY-156799 Cholesterol 24-hydroxylase-IN-2 Inhibitor / 否
HY-172205 CHL2310 Inhibitor / 否
HY-E70510 Human CYP46A1,Low-Reductase / 否
HY-E70511 Human CYP46A1,High-Reductase / 否
HY-RS03475 CYP46A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18437 Cyp46a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24919 Cyp46a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cyp46a1 NCBI NCBI:10858
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